(2,3-Dihydroxy-4,5,6-triphosphonooxycyclohexyl) dihydrogen phosphate

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2,3-Dihydroxy-4,5,6-triphosphonooxycyclohexyl) dihydrogen phosphate
• 化学式: C₆H₁₆O₁₈P₄
• 分子量: 500.08
• InChiKey: MRVYFOANPDTYBY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -8.1
• 重原子数：
  28
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  308
• 氢给体数：
  10
• 氢受体数：
  18

反应信息

• 作为产物：
  描述：

  dimethyl [4,6,7-tris(dimethoxyphosphoryloxy)-2,2-dimethyl-3a,4,5,6,7,7a-hexahydro-1,3-benzodioxol-5-yl] phosphate 生成 (2,3-Dihydroxy-4,5,6-triphosphonooxycyclohexyl) dihydrogen phosphate
  参考文献：
  名称：

  MEEK, JAMES L.;DAVIDSON, FRED;HOBBS, FRANK W. , JR., J. AMER. CHEM. SOC., 110,(1988) N 7, 2317-2318

  摘要：

  DOI：

文献信息

• Inositol derivatives for increasing chloride secretion and inhibiting inflammation
  申请人：——

  公开号：US20040147487A1

  公开（公告）日：2004-07-29

  Inositol derivatives, compositions comprising inositol derivatives, and methods for using compositions comprising inositol derivatives as agents for activating the secretion of chloride ions and/or treatment of inflammation are described.

  肌醇衍生物、包含肌醇衍生物的组成物以及使用包含肌醇衍生物的组成物作为激活氯离子分泌和/或治疗炎症的剂的方法被描述。
• [EN] CAMPHANYLIDENE AND PHENYLALKYL INOSITOL POLYPHOSPHATE COMPOUNDS, COMPOSITIONS, AND METHODS OF THEIR USE<br/>[FR] COMPOSES DE CAMPHANYLIDENE ET POLYPHOSPHATES D'INOSITOL PHENYLALKYLE, COMPOSITIONS ET LEURS PROCEDES D'UTILISATION
  申请人：INOLOGIC INC

  公开号：WO2004087721A1

  公开（公告）日：2004-10-14

  This invention relates to new camphanylidene and phenyl alkyl inositol polyphosphate derivatives that inhibit the absorption of sodium ions in epithelial cells and regulate inducible nitric oxide synthase (iNOS) in macrophages. The invention provides methods for inhibiting sodium ion absorption by epithelial cells and/or regulating inducible nitric oxide synthase (iNOS) in macrophages, by treating epithelial cells or administering to a patient in need of such treatment a therapeutically effective amount of camphanylidene and/or phenyl alkyl inositol polyphosphate compound. Representative camphanylidene and phenyl alkyl inositol polyphosphate compounds include, for example, 1,2-camphanylidene-myo-inositol 3,4,5,6-tetrakisphosphate octakis (propionoxymethyl) ester (INO-4996), 2,3-camphanylidene-myo-inositol 1,4,5,6­-tetrakisphosphate octakis (propionoxymethyl) ester (INO-4984) and 2-O-butyryl-1-O-(3-­phenylpropyl)-myo-inositol 3,4,5,6-tetrakisphosphate octakis (propionoxymethyl) ester (INO-4997).

  这项发明涉及新的松节醇亚烯基和苯基烷基肌醇多磷酸衍生物，能够抑制上皮细胞中钠离子的吸收并调节巨噬细胞中的诱导型一氧化氮合酶（iNOS）。该发明提供了通过治疗上皮细胞或向需要此类治疗的患者施用松节醇亚烯基和/或苯基烷基肌醇多磷酸化合物的治疗方法，以抑制上皮细胞中的钠离子吸收和/或调节巨噬细胞中的诱导型一氧化氮合酶（iNOS）。代表性的松节醇亚烯基和苯基烷基肌醇多磷酸化合物包括，例如，1,2-松节醇亚烯基-肌醇3,4,5,6-四磷酸八(丙酰氧甲基)酯（INO-4996）、2,3-松节醇亚烯基-肌醇1,4,5,6-四磷酸八(丙酰氧甲基)酯（INO-4984）和2-O-丁酰基-1-O-(3-苯基丙基)-肌醇3,4,5,6-四磷酸八(丙酰氧甲基)酯（INO-4997）。
• Regulation of ins(3456)p4 signalling by a reversible kinase phosphatase and methods and compositions related thereto
  申请人：Shears B Stephen

  公开号：US20060035810A1

  公开（公告）日：2006-02-16

  Provided is a method of increasing 3,4,5,6-tetrakisphosphate by increasing the activity of inositol 1,3,4,5,6 pentakisphosphate 1-phosphatase, and a method of decreasing 3,4,5,6-tetrakisphosphate by decreasing the activity of inositol 1,3,4,5,6 pentakisphosphate 1-phosphatase. A method of reducing salt, fluid or mucous secretion in a subject, comprising increasing the activity of inositol 1,3,4,5,6 pentakisphosphate 1-phosphatase in the subject is provided. A method of treating a disease that is exacerbated by salt, fluid or mucous secretion is also provided, comprising increasing the activity of inositol 1,3,4,5,6 pentakisphosphate phosphatase in a subject having a disease that is exacerbated by mucous, whereby mucous secretion is reduced and the disease is treated. Also provided is method of increasing salt and fluid secretion in a subject, comprising decreasing the activity of inositol 1,3,4,5,6 pentakisphosphate 1-phosphatase in the subject. A method of treating a disease that is treated by increased salt and fluid secretion is provided, comprising decreasing the activity of inositol 1,3,4,5,6 pentakisphosphate 1-phosphatase in a subject having a disease that is treated by increased salt and fluid secretion, whereby salt and fluid secretion is increased and the disease is treated.

  提供了一种通过增加肌醇1,3,4,5,6五磷酸1-磷酸酶的活性来增加3,4,5,6四磷酸盐的方法，以及通过降低肌醇1,3,4,5,6五磷酸1-磷酸酶的活性来减少3,4,5,6四磷酸盐的方法。提供了一种在受试对象中减少盐、液体或黏液分泌的方法，包括增加受试对象中肌醇1,3,4,5,6五磷酸1-磷酸酶的活性。还提供了一种治疗因盐、液体或黏液分泌加重的疾病的方法，包括增加患有因黏液分泌加重的疾病的受试对象中肌醇1,3,4,5,6五磷酸磷酸酶的活性，从而减少黏液分泌并治疗疾病。还提供了一种在受试对象中增加盐和液体分泌的方法，包括降低受试对象中肌醇1,3,4,5,6五磷酸1-磷酸酶的活性。提供了一种治疗因增加盐和液体分泌而治疗的疾病的方法，包括降低因增加盐和液体分泌而治疗的疾病的受试对象中肌醇1,3,4,5,6五磷酸1-磷酸酶的活性，从而增加盐和液体分泌并治疗疾病。
• MICROORGANISMS AND METHODS FOR PRODUCING 2,4-PENTADIENOATE, BUTADIENE, PROPYLENE, 1,3-BUTANEDIOL AND RELATED ALCOHOLS
  申请人：Osterhout Robin E.

  公开号：US20130109064A1

  公开（公告）日：2013-05-02

  The invention provides non-naturally occurring microbial organisms containing 2,4-pentadienoate, butadiene, propylene, 1,3-butanediol, crotyl alcohol or 3-buten-1-ol pathways comprising at least one exogenous nucleic acid encoding a butadiene pathway enzyme expressed in a sufficient amount to produce 2,4-pentadienoate, butadiene, propylene, 1,3-butanediol, crotyl alcohol or 3-buten-1-ol. The invention additionally provides methods of using such microbial organisms to produce 2,4-pentadienoate, butadiene, propylene, 1,3-butanediol, crotyl alcohol or 3-buten-1-ol, by culturing a non-naturally occurring microbial organism containing 2,4-pentadienoate, butadiene, propylene, 1,3-butanediol, crotyl alcohol or 3-buten-1-ol pathways as described herein under conditions and for a sufficient period of time to produce 2,4-pentadienoate, butadiene, propylene, 1,3-butanediol, crotyl alcohol or 3-buten-1-ol.

  本发明提供了不自然存在的微生物生物体，包含2,4-戊二烯酸、丁二烯、丙烯、1,3-丁二醇、烯丙醇或3-丁烯-1-醇途径，其中包括至少一个外源核酸编码的丁二烯途径酶，在足够数量下表达以产生2,4-戊二烯酸、丁二烯、丙烯、1,3-丁二醇、烯丙醇或3-丁烯-1-醇。此外，本发明提供了使用这种微生物生物体生产2,4-戊二烯酸、丁二烯、丙烯、1,3-丁二醇、烯丙醇或3-丁烯-1-醇的方法，通过在适当的条件下培养包含2,4-戊二烯酸、丁二烯、丙烯、1,3-丁二醇、烯丙醇或3-丁烯-1-醇途径的不自然存在的微生物生物体，并在足够的时间内产生2,4-戊二烯酸、丁二烯、丙烯、1,3-丁二醇、烯丙醇或3-丁烯-1-醇。
• MICROORGANISMS AND METHODS FOR PRODUCING ALKENES
  申请人：Burk Mark J.

  公开号：US20130122563A1

  公开（公告）日：2013-05-16

  The invention provides non-naturally occurring microbial organisms containing an alkene pathway having at least one exogenous nucleic acid encoding an alkene pathway enzyme expressed in a sufficient amount to convert an alcohol to an alkene. The invention additionally provides methods of using such microbial organisms to produce an alkene, by culturing a non-naturally occurring microbial organism containing an alkene pathway as described herein under conditions and for a sufficient period of time to produce an alkene.

  本发明提供了非自然存在的微生物生物体，其含有至少一种外源核酸编码的烯烃途径酶，表达量足以将醇转化为烯烃。本发明还提供了使用这种微生物生物体生产烯烃的方法，通过在适当的条件和足够的时间下培养含有如上所述的烯烃途径的非自然存在的微生物生物体，以产生烯烃。