2-(Hydroxymethyl)-6-(4-methylphenoxy)oxane-3,4,5-triol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(Hydroxymethyl)-6-(4-methylphenoxy)oxane-3,4,5-triol
• 化学式: C₁₃H₁₈O₆
• 分子量: 270.28
• InChiKey: MVLBSNPILSLTFZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  99.4
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• COMPOUNDS AND METHODS FOR TREATING BACTERIAL INFECTIONS
  申请人：Janetka James W.

  公开号：US20120309701A1

  公开（公告）日：2012-12-06

  The present invention encompasses compounds and methods for treating urinary tract infections.

  本发明涵盖了治疗尿路感染的化合物和方法。
• ANTI-EGFR ANTIBODY DRUG CONJUGATES
  申请人：AbbVie Inc.

  公开号：EP4104865A1

  公开（公告）日：2022-12-21

  The invention relates to anti-Epidermal Growth Factor Receptor (EGFR) antibody drug conjugates (ADCs) which inhibit Bcl-xL, including compositions and methods of using said ADCs.

  本发明涉及抑制 Bcl-xL 的抗表皮生长因子受体（EGFR）抗体药物共轭物（ADC），包括使用所述 ADC 的组合物和方法。
• Mannose-derived antagonists of FimH useful for treating disease
  申请人：Fimbrion Therapeutics, Inc.

  公开号：US10738070B2

  公开（公告）日：2020-08-11

  The present invention relates to mannoside derivative compounds useful as inhibitors of FimH and methods for the treatment or prevention of urinary tract infection.

  本发明涉及可用作 FimH 抑制剂的甘露糖苷衍生物化合物以及治疗或预防尿路感染的方法。
• MANNOSE-DERIVED ANTAGONISTS OF FIMH USEFUL FOR TREATING DISEASE
  申请人：Fimbrion Therapeutics, Inc.

  公开号：US20190106451A1

  公开（公告）日：2019-04-11

  The present invention relates to mannoside derivative compounds useful as inhibitors of FimH and methods for the treatment or prevention of urinary tract infection.
• BIVALENT LECA INHIBITORS TARGETING BIOFILM FORMATION OF PSEUDOMONAS AERUGINOSA
  申请人：HELMHOLTZ-ZENTRUM FÜR INFEKTIONSFORSCHUNG GMBH

  公开号：US20220402960A1

  公开（公告）日：2022-12-22

  The present invention relates to divalent compounds binding to LecA. The compounds are useful to block biofilm formation of Pseudomonas aeruginosa . The invention further relates to pharmaceutical compositions comprising these compounds and to therapeutic methods and uses of these compounds, in particular to therapeutic methods and uses for the treatment of Pseudomonas aeruginosa infections in a subject. The invention also relates to imaging of infections, such as biofilms produced by Pseudomonas aeruginosa , by using these divalent compounds.