Ovalicine subst. | 19683-98-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Ovalicine subst.
• 英文别名: 4-hydroxy-5-methoxy-4-[2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-one
• CAS: 19683-98-8
• 化学式: C₁₆H₂₄O₅
• 分子量: 296.36
• InChiKey: NESRXFGQJARQNM-UHFFFAOYSA-N

物化性质

• 熔点：
  94-95 °C
• 沸点：
  443.8±45.0 °C(Predicted)
• 密度：
  1.21±0.1 g/cm3(Predicted)
• LogP：
  -0.136 (est)
• 物理描述：
  Solid

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.81
• 拓扑面积：
  71.6
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Pharmaceutical composition for the treatment of seborrhea containing 4-hydroxy-5-methoxy-4-[2-methyl-3(3-methyl-2-butenyl)-2-oxiranyl]-1-oxaspiro[2,5]octan-6-one
  申请人：Yoon Cheol-Sik

  公开号：US20050124690A1

  公开（公告）日：2005-06-09

  Disclosed is a pharmaceutical composition containing a pharmaceutically effective amount of 4-hydroxy-5-methoxy-4-[2-methyl-3-(methyl-2-butenyl)-2-oxiranyl]-1-oxaspiro[2,5]octan-6-one, which is capable of preventing or treating seborrhea caused by a fungus, Pityrosporum ovale.

  本发明公开了一种药物组合物，其中含有药用有效量的 4-羟基-5-甲氧基-4-[2-甲基-3-(甲基-2-丁烯基)-2-环氧乙烷基]-1-氧杂螺[2,5]辛-6-酮，能够预防或治疗由真菌引起的脂溢性脱发、 Pityrosporum ovale）引起的皮脂溢出症。
• A PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF SEBORRHEA CONTAINING 4-HYDROXY-5-METHOXY-4- 2-METHYL-3(3-METHYL-2-BUTENYL)-2-OXIRANYL]-1-OXASPIRO 2,5]OCTAN-6-ONE
  申请人：Mycoplus Co., Ltd.

  公开号：EP1509220A1

  公开（公告）日：2005-03-02
• EP1509220A4
  申请人：——

  公开号：EP1509220A4

  公开（公告）日：2009-04-01
• TERPENES WITH ANTIFUNGAL ACTIVITY AGAINST MALASSEZIA YEASTS
  申请人：Canedo Hernandez Librada Maria

  公开号：US20100184853A1

  公开（公告）日：2010-07-22

  The present invention relates to the use of some terpenes, for example chlovalicin, ovalicin or fumagillin, as antifungal against Malassezia species and to their use in the manufacture of medicaments for the treatment of human skin diseases caused by these Malassezia species, such as pityriasis versicolor, seborrheic dermatitis, dandruff, atopic dermatitis, psoriasis, confluent and reticulated papillomatosis, onychomycosis, and transient acantholytic dermatosis.
• [EN] A PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF SEBORRHEA CONTAINING 4-HYDROXY-5-METHOXY-4-[2-METHYL-3(3-METHYL-2-BUTENYL)-2-OXIRANYL]-1-OXASPIRO[2,5]OCTAN-6-ONE<br/>[FR] COMPOSITION PHARMACEUTIQUE DESTINE AU TRAITEMENT DE LA SEBORRHEE CONTENANT 4-HYDROXY-5-METHOXY-4-[2-METHYL-3-(3-METHYL-2-BUTENYL)-2-OXIRANYL]-1-OXASPIRO[2,5]OCTANE-6-ONE
  申请人：MYCOPLUS CO LTD

  公开号：WO2003094908A1

  公开（公告）日：2003-11-20

  Disclosed is a pharmaceutical composition containing a pharmaceutically effective amount of 4-hydroxy-5-methoxy-4-[2-methyl-3-(methyl-2-butenyl)-2-oxiranyl]-1-oxaspiro[2,5]octan-6-one, which is capable of preventing or treating seborrhea caused by a fungus, Pityrosporum ovale.