indoline-2,3-dione-2-oxime | 3265-35-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: indoline-2,3-dione-2-oxime
• 英文别名: Isatin-2-oxim；α-isatine oxime；Indolin-2,3-dion-2-oxim；indole-2,3-dione, 2-oxime；2-(hydroxyamino)indol-3-one
• CAS: 3265-35-8
• 化学式: C₈H₆N₂O₂
• 分子量: 162.148
• InChiKey: NGXLTYPELAIUHE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.08
• 重原子数：
  12.0
• 可旋转键数：
  0.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  61.69
• 氢给体数：
  2.0
• 氢受体数：
  3.0

安全信息

• 海关编码：
  2933990090

反应信息

• 作为反应物：
  描述：

  indoline-2,3-dione-2-oxime 生成 2-氨基苯甲腈
  参考文献：
  名称：

  Borsche; Weussmann; Fritzsche, Chemische Berichte, 1924, vol. 57, p. 1151

  摘要：

  DOI：
• 作为产物：
  描述：

  N-乙酰基-3-吲哚啉酮 在 盐酸 、 乙醇 、 水 、 溶剂黄146 、 丙酮 、 sodium nitrite 作用下， 生成 indoline-2,3-dione-2-oxime
  参考文献：
  名称：

  Etienne, Bulletin de la Societe Chimique de France, 1948, p. 651,654

  摘要：

  DOI：

文献信息

• Certain 1H-pyrrold[3,4-b]quinolin-1-one-9-amino-2,3-dihydro derivatives
  申请人：ICI Americas Inc.

  公开号：US04975435A1

  公开（公告）日：1990-12-04

  The present invention comprises certain quinoline lactams of formula I; pharmaceutically acceptable salts of the compounds of formula I; pharmaceutical compositions containing a compound of formula I, or a pharmaceutically acceptable salt thereof, for use in the treatment of anxiety; and processes for the manufacture of the compounds of formula I, as well as intermediates for use in such manufacture.

  本发明涵盖了某些式I的喹啉内酰胺；式I化合物的药学上可接受的盐；含有式I化合物或其药学上可接受的盐的药物组合物，用于治疗焦虑；以及用于制造式I化合物的工艺，以及用于此类制造的中间体。
• Process for preparing isatins with control of side-product formation
  申请人：Wilk Kazimierz Bogdan

  公开号：US20060247442A1

  公开（公告）日：2006-11-02

  Methods and kits for preventing or minimizing the formation of isatin oximes during formation of an isatin from an isonitrosoacetanilide are provided. Also provided are methods and kits for preventing or minimizing the formation of isatin oxime impurities after formation of an isatin from an isonitrosoacetanilide by using a decoy agent in the quenching and/or extraction steps. The isatins can be prepared using a decoy agent and desirably a strong acid. Further provided are methods for preparing isatin oximes.

  提供了一种防止或最小化在从异硝基乙酰苯胺制备异吲哚时形成异吲哚肟的方法和试剂盒。还提供了一种使用诱饵剂在淬灭和/或提取步骤中防止或最小化从异硝基乙酰苯胺制备异吲哚后形成异吲哚肟杂质的方法和试剂盒。可以使用诱饵剂和强酸制备异吲哚。还提供了制备异吲哚肟的方法。
• [EN] USE OF ISATIN DERIVATIVES AS ION CHANNEL ACTIVATING AGENTS<br/>[FR] UTILISATION DE DERIVES D'ISATINE EN TANT QU'AGENTS D'ACTIVATION DE CANAUX IONIQUES
  申请人：NEUROSEARCH AS

  公开号：WO2000033834A1

  公开（公告）日：2000-06-15

  The present invention relates to ion channel activating agents. More particularly, the present invention relates to a particular class of chemical compounds that has proven useful as openers of SKCa and IKCa channels. In further aspects, the present invention relates to the use of these SK/IK channel activating agents for the manufacture of medicaments, and pharmaceutical compositions comprising the SK/IK channel activating agents. The SK/IK channel activating agents of the invention are useful for the treatment or alleviation of diseases and conditions associated with the SK/IK channels, in particular respiratory diseases such as asthma, cystic fibrosis, chronic obstructive pulmonary disease and rhinorrhea, convulsions, vascular spasms, coronary artery spasms, renal disorders, polycystic kidney disease, bladder spasms, urinary incontinence, bladder outflow obstruction, irritable bowel syndrome, gastrointestinal dysfunction, secretory diarrhoea, ischaemia, cerebral ischaemia, ischaemic hearth disease, angina pectoris, coronary hearth disease, traumatic brain injury, psychosis, anxiety, depression, dementia, memory and attention deficits, Alzheimer's disease, dysmenorrhea, narcolepsy, Reynaud's disease, intermittent claudication, Sjorgren's syndrome, migraine, arrhythmia, hypertension, absence seizures, myotonic muscle dystrophia, xerostomi, diabetes type II, hyperinsulinemia, premature labour, baldness, cancer, and immune suppression.

  本发明涉及离子通道激活剂。更具体地，本发明涉及一类已被证明对SKCa和IKCa通道具有开放作用的化学化合物。在进一步方面，本发明涉及使用这些SK/IK通道激活剂制造药物，以及包括SK/IK通道激活剂的药物组合物。本发明的SK/IK通道激活剂对于治疗或缓解与SK/IK通道相关的疾病和症状非常有用，特别是呼吸系统疾病，如哮喘、囊性纤维化、慢性阻塞性肺疾病和流涕、惊厥、血管痉挛、冠状动脉痉挛、肾功能障碍、多囊肾病、膀胱痉挛、尿失禁、膀胱出口梗阻、肠易激综合征、胃肠功能障碍、分泌性腹泻、缺血、脑缺血、缺血性心脏病、心绞痛、冠心病、创伤性脑损伤、精神病、焦虑、抑郁症、痴呆、记忆和注意力缺陷、阿尔茨海默病、痛经、嗜睡症、雷诺氏病、间歇性跛行、Sjogren综合征、偏头痛、心律失常、高血压、失神发作、肌肉萎缩症、口干症、2型糖尿病、高胰岛素血症、早产、秃发、癌症和免疫抑制等。
• Method of preparing enantiomers of indole-2,3-dione-3-oxime derivatives
  申请人：Gouliaev H Alex

  公开号：US20060178391A1

  公开（公告）日：2006-08-10

  The present invention is directed to a method of preparing enantiomers of indole-2,3-dione-3-oxime derivatives.

  本发明涉及一种制备吲哚-2,3-二酮-3-肟衍生物对映体的方法。
• Compositions and methods for modulating gated ion channels
  申请人：Vohra Rahul

  公开号：US20080004272A1

  公开（公告）日：2008-01-03

  The present invention relates to compositions and methods to modulate the activity of gated ion channels.

  本发明涉及用于调节门控离子通道活性的组合物和方法。