(3,6,9-Trimethyl-2,7-dioxo-3,3a,4,5,9a,9b-hexahydroazuleno[4,5-b]furan-4-yl) 2-phenylacetate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: (3,6,9-Trimethyl-2,7-dioxo-3,3a,4,5,9a,9b-hexahydroazuleno[4,5-b]furan-4-yl) 2-phenylacetate
• 化学式: C₂₃H₂₄O₅
• 分子量: 380.4
• InChiKey: NNLJICJPZZZIFI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  69.7
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• MC-1 R, MC-2 R, and µ opioid receptors modulation
  申请人：BASF Beauty Care Solutions France SAS

  公开号：EP2574332A1

  公开（公告）日：2013-04-03

  The invention concerns active substances modulating the expression of the receptors of the products of the POMC gene (MC-1R, MC-2R, and the µ opioid receptor), and possibly modulating the expression of POMC in cutaneous cells, notably to modulate the proliferation and differentiation of epidermal cells in order to re-epithelial, maintain innervation, irrigate the skin, or restore normal pigmentation, or to fight against aging, or to modulate pigmentation independently or not of cutaneous aging. The invention also concerns a method of screening such active substances.

  本发明涉及调节 POMC 基因产物（MC-1R、MC-2R 和 µ 阿片受体）受体表达的活性物质，以及可能调节皮肤细胞中 POMC 表达的活性物质，特别是调节表皮细胞的增殖和分化，以重新上皮、维持神经支配、灌溉皮肤、或恢复正常色素沉着、或抗衰老、或调节色素沉着，无论是否与皮肤衰老无关。 本发明还涉及一种筛选此类活性物质的方法。
• MC-1R, MC-2R, AND/OR µ OPIOID RECEPTORS STIMULATION
  申请人：BASF Beauty Care Solutions France SAS

  公开号：EP2157966A2

  公开（公告）日：2010-03-03
• MC-1 R, MC-2 R, AND MU OPIOID RECEPTORS MODULATION
  申请人：BASF Beauty Care Solutions France SAS

  公开号：EP2157978A2

  公开（公告）日：2010-03-03
• MC-1R, MC-2R, AND/OR MU OPIOID RECEPTORS MODULATION
  申请人：Pain Sabine

  公开号：US20100209407A1

  公开（公告）日：2010-08-19

  The invention concerns active substances modulating the expression of the receptors of the products of the POMC gene (MC-IR, MC-2R, and the μ opioid receptor), and possibly modulating the expression of POMC in cutaneous cells, notably to modulate the proliferation and differentiation of epidermal cells in order to re-epithelial, maintain innervation, irrigate the skin, or restore normal pigmentation, or to fight against aging, or to modulate pigmentation independently or not of cutaneous aging. The invention also concerns a method of screening such active substances.
• MC-1R, MC-2R, and/or µ OPIOID RECEPTORS STIMULATION
  申请人：Pain Sabine

  公开号：US20100272699A1

  公开（公告）日：2010-10-28

  The invention concerns active substances modulating the expression of the receptors of the products of the POMC gene (MC-IR, MC-2R, and the μ opioid receptor), and possibly modulating the expression of POMC in cutaneous cells, notably to modulate the proliferation and differentiation of epidermal cells in order to re-epithelial, maintain innervation, irrigate the skin, or to fight against aging, or to modulate pigmentation independently or not of cutaneous aging. The invention also concerns a method of screening such active substances.