4-Methoxy-6-methyloxane-2,3,5-triol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-Methoxy-6-methyloxane-2,3,5-triol
• 化学式: C₇H₁₄O₅
• 分子量: 178.18
• InChiKey: OEKPKBBXXDGXNB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.6
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  79.2
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• AGENTS FOR MODULATION OF WNT-TCF SIGNALLING AND USES THEREOF
  申请人：UNIVERSITE DE GENEVE

  公开号：EP3248604A1

  公开（公告）日：2017-11-29

  The present invention relates to inhibitors of WNT-TCF signalling and compositions thereof. The invention further relates to use of those inhibitors of WNT-TCF signalling and compositions thereof for the treatment and/or prevention and/or prevention of recurrence of a WNT-activated cancer and/or a cancer associated with the cancer stem cells. the active compounds are certain cardenolides and bufanolides.

  本发明涉及WNT-TCF信号的抑制剂及其组合物。本发明还涉及将这些 WNT-TCF 信号抑制剂及其组合物用于治疗和/或预防和/或防止 WNT 激活的癌症和/或与癌症干细胞相关的癌症复发。
• [EN] AGENTS FOR MODULATION OF WNT-TCF SIGNALLING AND USES THEREOF<br/>[FR] AGENTS POUR LA MODULATION DE LA SIGNALISATION WNT-TCF ET LEURS UTILISATIONS
  申请人：UNIV GENEVE

  公开号：WO2017203062A1

  公开（公告）日：2017-11-30

  The present invention relates to inhibitors of WNT-TCF signalling and compositions thereof. The invention further relates to use of those inhibitors of WNT-TCF signalling and compositions thereof for the treatment and/or prevention and/or prevention of recurrence of a WNT-activated cancer and/or a cancer associated with the cancer stem cells.