2-deoxy-6-O-sulfo-2-(sulfoamino)-4-O-(2-O-sulfohexopyranuronosyl)hexopyranose

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-deoxy-6-O-sulfo-2-(sulfoamino)-4-O-(2-O-sulfohexopyranuronosyl)hexopyranose
• 英文别名: 6-[4,6-dihydroxy-5-(sulfoamino)-2-(sulfooxymethyl)oxan-3-yl]oxy-3,4-dihydroxy-5-sulfooxyoxane-2-carboxylic acid
• 化学式: C₁₂H₂₁NO₂₀S₃
• 分子量: 595.5
• InChiKey: OHJKXVLJWUPWQG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -6
• 重原子数：
  36
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  365
• 氢给体数：
  9
• 氢受体数：
  21

文献信息

• FORMULATIONS COMPRISING CYCLIC COMPOUNDS
  申请人：Botti Paolo

  公开号：US20100137188A1

  公开（公告）日：2010-06-03

  This invention relates to the use of a cyclic compound of formula (I) wherein A, B independently in each occurrence is alkane-i,j-diyl having k carbon atoms, i and independently j being less than or equal k and k being selected from 1 to 10, wherein said alkane-i,j-diyl (i) may comprise one or more double bonds; (ii) is optionally substituted; and/or (iii) comprises a cycle, wherein the total number of cycles being cyclic sugars in said compound is selected from 0 to 4 and is less than p·n+m); X,Y independently in each occurrence is a biocompatible functional group comprising at least one oxygen atom or two sulphur atoms; n, m independently of each other are selected from 0 to 20; p is selected from 1 to 10; n+m is equal or greater than 1; and p·(n+m) is selected from 3 to 30; wherein said compound is capable of forming a complex with a protonated primary and/or protonated secondary amino group and/or a protonated guanidinium group for the manufacture of a pharmaceutical or diagnostic composition further comprising a pharmaceutically or diagnostically active agent, said active agent comprising one or more protonated primary and/or protonated secondary amino groups and/or a protonated guanidinium groups, wherein (a) transmembrane and/or transmucosal delivery; (b) solubility in non-aqueous solvents; and/or (c) stability of said active agent are improved.
• CAR PEPTIDE FOR HOMING, DIAGNOSIS & TARGETED THERAPY FOR PULMONARY AND FIBROTIC DISORDERS
  申请人：Vascular BioSciences

  公开号：US20190134211A1

  公开（公告）日：2019-05-09

  Disclosed are compositions and methods useful for delivering targeted therapies for pulmonary diseases, fibrotic disorders and cancer. The compositions and methods are based on peptide sequences that selectively bind to and home to diseased tissue and enable targeted therapies to effect a beneficial therapeutic result. The disclosed targeting is useful for delivering therapeutic and detectable agents to diseased tissue in an animal.
• US8513188B2
  申请人：——

  公开号：US8513188B2

  公开（公告）日：2013-08-20