3-Amino-5-hydroxy-7-oxabicyclo[4.1.0]hept-3-en-2-one

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-Amino-5-hydroxy-7-oxabicyclo[4.1.0]hept-3-en-2-one
• 英文别名: 3-amino-5-hydroxy-7-oxabicyclo[4.1.0]hept-3-en-2-one
• 化学式: C₆H₇NO₃
• 分子量: 141.12
• InChiKey: OIXFFAVTKPAUAU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  75.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Processes and host cells for genome, pathway, and biomolecular engineering
  申请人：enEvolv, Inc.

  公开号：US10370654B2

  公开（公告）日：2019-08-06

  The present disclosure provides compositions and methods for genomic engineering.

  本公开提供了基因组工程的组合物和方法。
• PROCESSES AND HOST CELLS FOR GENOME, PATHWAY, AND BIOMOLECULAR ENGINEERING
  申请人：enEvolv, Inc.

  公开号：EP3027754A1

  公开（公告）日：2016-06-08
• Manumycin-type metabolite called Colabomycin E which inhibits caspase 1 and creation of interleukins, strain produces the Colabomycin E and a method of a production of the Colabomycin E
  申请人：BIOLOGY CENTRE AS CR, v. v. i.,

  公开号：US20160168106A1

  公开（公告）日：2016-06-16

  A manumycin-type metabolite called Colabomycin E which inhibits caspase 1 and creation of interleukins, strain produces the Colabomycin E and a method of a production of the Colabomycin E. Colabomycin E is a new member of the manumycin-type metabolites produced by the strain Streptomyces aureus SOK1/5-04 deposited in The Czech collection of microorganisms under number CCM8556. The structure of 5 is similar to that of the already known metabolite colabomycin A (3) isolated from Streptomyces griseoflavus . However, the upper polyene chain of 5 is two carbons longer. Therefore, it was named Colabomycin E. Biological activity assays indicated that colabomycin E significantly inhibited IL-1β release from THP-1 cells and might thus potentially act as an anti-inflammatory agent.
• US9447062B2
  申请人：——

  公开号：US9447062B2

  公开（公告）日：2016-09-20
• US9944925B2
  申请人：——

  公开号：US9944925B2

  公开（公告）日：2018-04-17