5-(Methylsulfanylmethyl)oxolane-2,3,4-triol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-(Methylsulfanylmethyl)oxolane-2,3,4-triol
• 化学式: C₆H₁₂O₄S
• 分子量: 180.22
• InChiKey: OLVVOVIFTBSBBH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  95.2
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Anti-LAM and anti-PIM6/LAM monoclonal antibodies for diagnosis and treatment of Mycobacterium tuberculosis infections
  申请人：Rutgers, The State University of New Jersey

  公开号：US10729771B2

  公开（公告）日：2020-08-04

  The present invention broadly provides different compositions, kits, vectors, and methods including monoclonal antibodies directed to epitopes found within lipoarabinomannan (LAM) and phosphatidyl-myo-inositol mannoside 6 (PIM6) for the diagnosis and treatment of Mycobacterium tuberculosis infections.

  本发明广泛地提供了不同的组合物、试剂盒、载体和方法，包括针对脂质阿拉伯甘露聚糖（LAM）和磷脂酰肌醇甘露糖苷 6（PIM6）表位的单克隆抗体，用于结核分枝杆菌感染的诊断和治疗。
• NOVEL ANTI-LAM AND ANTI-PIM6/LAM MONOCLONAL ANTIBODIES FOR DIAGNOSIS AND TREATMENT OF MYCOBACTERIUM TUBERCULOSIS INFECTIONS
  申请人：Rutgers, the State University of New Jersey

  公开号：EP3414573A1

  公开（公告）日：2018-12-19
• METHODS FOR DUAL DETECTION AND DIFFERENTIATION OF INFECTION BY MYCOBACTIERUM TUBERCULOSIS COMPLEX AND NONTUBERCULOUS MYCOBACTERIA
  申请人：Rutgers, the State University of New Jersey

  公开号：EP3823670A1

  公开（公告）日：2021-05-26
• METHODS AND COMPOSITIONS FOR TREATING BACTERIAL INFECTIONS BY INHIBITING QUORUM SENSING
  申请人：Schramm Vern L.

  公开号：US20110190265A1

  公开（公告）日：2011-08-04

  The present invention provides methods for treating bacterial infections in a subject comprising administering to the subject a sub-growth inhibiting amount of a 5′-Methylthioadenosine/S-adenosyl homocysteine nucleosidase (MTAN) inhibitor. The present invention further provides pharmaceutical compositions comprising a sub-bacterial-growth inhibiting amount of a 5′-Methylthioadenosine/S-adenosyl homocysteine nucleosidase (MTAN) inhibitor and a pharmaceutically acceptable carrier.
• METHODS FOR DUAL DETECTION AND DIFFERENTIATION OF INFECTION BY MYCOBACTERIUM TUBERCULOSIS COMPLEX AND NONTUBERCULOUS MYCOBACTERIA
  申请人：Rutgers, The State University of New Jersey

  公开号：US20210302424A1

  公开（公告）日：2021-09-30

  This disclosure provides novel binary and ternary diagnostic tests with improved sensitivity and specificity for the presence of antigenic derivatives of lipo arabino mannan (LAM) present in biological fluids (e.g., sputum, serum, urine) of subjects infected with various mycobacterial pathogens, including M. tb and NTMs. The disclosed diagnostic tests detect and differentiate infection by Mycobacterium tuberculosis complex (MTBC) and nontuberculous mycobacteria (NTMs). The diagnostic tests detect different forms of LAM in the sample of patients, using capture antibodies that are either specific for TB, specific for NTMs or crossreactive with all forms of LAM, in conjunction with high-affinity species-specific or crossreactive detection antibodies.