3-(5,6-dichloro-2,4-dimethylhexanoyl)-2-hydroxy-5,6-dimethoxy-1H-pyridin-4-one | 146726-73-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-(5,6-dichloro-2,4-dimethylhexanoyl)-2-hydroxy-5,6-dimethoxy-1H-pyridin-4-one
• 英文别名: 3-(5,6-dichloro-2,4-dimethylhexanoyl)-4-hydroxy-5,6-dimethoxy-1H-pyridin-2-one
• CAS: 146726-73-0
• 化学式: C₁₅H₂₁Cl₂NO₅
• 分子量: 366.2
• InChiKey: OVULNOOPECCZRG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  23
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  84.9
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• INHIBITORS AGAINST COMPLEX II OF ELECTRON TRANSPORT SYSTEM
  申请人：THE KITASATO INSTITUTE

  公开号：EP1512402B1

  公开（公告）日：2007-10-31
• Uses of Bcl-2 Antagonists for Treating Cancer and Diagnostics Related Thereto
  申请人：Emory University

  公开号：US20190328729A1

  公开（公告）日：2019-10-31

  In certain embodiments, this disclosure relates to method of treating and diagnosing cancer by administering a Bcl-2 inhibitor optionally in combination with a mitochondrial complex II inhibitor. In certain embodiments, a subject is diagnosed with, exhibiting symptoms of, or at risk of cancer wherein the cancer is a hematological malignancy such as multiple myeloma, leukemia, or lymphoma.
• TARGETING MITOCHONDRIAL COMPLEX II TO REDUCE EFFECTS OF CHRONIC HYPOXIA
  申请人：Health Research, Inc.

  公开号：US20200375963A1

  公开（公告）日：2020-12-03

  Provided are methods for treatment of chronic systemic hypoxia. The method comprises administration of an inhibitor of mitochondrial complex II (MTCII). An example of an MTCII inhibitor is Atpenin 5.
• US7514455B2
  申请人：——

  公开号：US7514455B2

  公开（公告）日：2009-04-07