3,4-dichloro-5-[(2,2-dimethyl-1,3-dioxolan-4-yl)methylamino]-2(5H)-furanone | 1246529-03-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3,4-dichloro-5-[(2,2-dimethyl-1,3-dioxolan-4-yl)methylamino]-2(5H)-furanone
• 英文别名: 3,4-dichloro-2-[(2,2-dimethyl-1,3-dioxolan-4-yl)methylamino]-2H-furan-5-one
• CAS: 1246529-03-2
• 化学式: C₁₀H₁₃Cl₂NO₄
• 分子量: 282.124
• InChiKey: ARVXEHYJAWPETB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  56.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  (3,4-二氯-5-氧代-2H-呋喃-2-基)乙酸酯 、 2,2-二甲基-1,3-二氧戊环-4-甲胺 以 二氯甲烷 为溶剂， 以25%的产率得到3,4-dichloro-5-[(2,2-dimethyl-1,3-dioxolan-4-yl)methylamino]-2(5H)-furanone
  参考文献：
  名称：

  Synthesis and preliminary bioactivity assays of 3,4-dichloro-5-(ω-hydroxyalkylamino)-2(5H)-furanones

  摘要：

  5-(omega-Hydroxyalkylamino) derivatives of mucochloric acids were synthesized through a facile substitution reaction of 3,4-dichloro-5-hydroxy-2(5H)-furanone (mucochloric acid) acetate or 5-methylcarbonate with an appropriate amino alcohol or aminodiol. The obtained products were characterized and screened for their antibacterial and antiprotozoal activities. (C) 2010 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2010.05.055

文献信息

• Synthesis and preliminary bioactivity assays of 3,4-dichloro-5-(ω-hydroxyalkylamino)-2(5H)-furanones
  作者：Edyta Gondela、Krzysztof Z. Walczak

  DOI：10.1016/j.ejmech.2010.05.055

  日期：2010.9

  5-(omega-Hydroxyalkylamino) derivatives of mucochloric acids were synthesized through a facile substitution reaction of 3,4-dichloro-5-hydroxy-2(5H)-furanone (mucochloric acid) acetate or 5-methylcarbonate with an appropriate amino alcohol or aminodiol. The obtained products were characterized and screened for their antibacterial and antiprotozoal activities. (C) 2010 Elsevier Masson SAS. All rights reserved.