4,5,6-Trihydroxy-2-oxo-7-phosphonooxyheptanoic acid

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4,5,6-Trihydroxy-2-oxo-7-phosphonooxyheptanoic acid
• 化学式: C₇H₁₃O₁₀P
• 分子量: 288.15
• InChiKey: PJWIPEXIFFQAQZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4
• 重原子数：
  18
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  182
• 氢给体数：
  6
• 氢受体数：
  10

文献信息

• UTILIZATION OF PHOSPHOKETOLASE FOR PRODUCTION OF AROMATIC AMINO ACID DERIVED PRODUCTS
  申请人：Danmarks Tekniske Universitet

  公开号：EP3656857A1

  公开（公告）日：2020-05-27

  The invention provides a genetically modified microorganism for production of aromatic amino acid derivatives; where the microorganism is capable of expressing enhanced levels of DAHP synthase and chorismate mutase, and further comprises transgenes encoding polypeptides having enzymatic activity of phosphoketolase and phosphate acetyltransferase. The invention further provides a method for producing aromatic amino acid derivatives using the genetically modified microorganism of the invention; as well as the use of the genetically modified microorganism for aromatic amino acid derivatives production.

  本发明提供了一种用于生产芳香族氨基酸衍生物的转基因微生物；其中该微生物能够表达更高水平的DAHP合成酶和氯氨酸突变酶，并进一步包含编码具有磷酸酮酶和磷酸乙酰转移酶酶活性的多肽的转基因。本发明进一步提供了一种利用本发明的转基因微生物生产芳香族氨基酸衍生物的方法；以及利用转基因微生物生产芳香族氨基酸衍生物的方法。
• CORYNEFORM BACTERIUM TRANSFORMANT AND METHOD FOR PRODUCING 2-PHENOL ETHANOL USING SAME
  申请人：Research Institute Of Innovative Technology For The Earth

  公开号：EP3901268A1

  公开（公告）日：2021-10-27

  Provided is a microorganism that is able to produce 2-phenylethanol at a high concentration, and a method of efficiently producing 2-phenylethanol by using a saccharide as a raw material. Provided is a coryneform bacterium transformant in which a shikimate pathway is activated, and further, a gene that encodes an enzyme having phenylpyruvate decarboxylase activity is introduced in such a manner that the gene can be expressed. Also provided is a 2-phenylethanol producing method that includes causing the coryneform bacterium transformant according to the present disclosure to react in water containing a saccharide.

  本发明提供了一种能够高浓度生产 2-苯基乙醇的微生物，以及一种以糖类为原料高效生产 2-苯基乙醇的方法。 本发明提供了一种子囊菌转化体，在该转化体中，莽草酸途径被激活，此外，还以能够表达该基因的方式导入了编码具有苯丙酮酸脱羧酶活性的酶的基因。 此外，还提供了一种生产 2-苯基乙醇的方法，该方法包括使根据本公开内容的子囊菌转化体在含有糖的水中进行反应。
• Coryneform bacterium transformant and process for producing organic compound using the same
  申请人：RESEARCH INSTITUTE OF INNOVATIVE TECHNOLOGY FOR THE EARTH

  公开号：US10208313B2

  公开（公告）日：2019-02-19

  A coryneform bacterium transformant engineered by the following (A) to (D): (A) enhancement of 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase activity; (B) prevention, inhibition, or reduction of intracellular sugar uptake mediated by phosphotransferase system (PTS); (C) enhancement of intracellular sugar uptake activity mediated by a sugar transporter different from phosphotransferase system and enhancement of glucokinase activity; and (D) enhancement of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) activity is capable of efficiently producing shikimic acid or the like from a sugar.

  由下列（A）至（D）项改造的球孢杆菌转化体：(A) 提高 3-脱氧-D-阿拉伯糖基-庚糖酸-7-磷酸（DAHP）合成酶的活性； (B) 防止、抑制或减少由磷酸转移酶系统（PTS）介导的细胞内糖吸收；(D) 提高甘油醛-3-磷酸脱氢酶（GAPDH）的活性，能够有效地从糖中产生莽草酸或类似物质。
• Coryneform bacterial transformant and method for producing 4-aminobenzoic acid or salt thereof using same
  申请人：RESEARCH INSTITUTE OF INNOVATIVE TECHNOLOGY FOR THE EARTH

  公开号：US10988743B2

  公开（公告）日：2021-04-27

  Provided is a microorganism that is capable of efficiently producing para-aminobenzoic acid (4-ABA) or a salt thereof, using saccharides as raw materials, and a method for efficiently producing 4-ABA or a salt thereof by using this microorganism. A transformant obtained by introducing, into a coryneform bacterium, a gene that encodes 4-amino-4-deoxychorismate lyase, a gene that encodes a para-aminobenzoate synthase component I, and a gene that encodes a para-aminobenzoate synthase component II, is capable of efficiently producing 4-ABA or a salt thereof from saccharides.

  本发明提供了一种能够以糖类为原料高效生产对氨基苯甲酸（4-ABA）或其盐的微生物，以及利用这种微生物高效生产 4-ABA 或其盐的方法。 将编码 4-氨基-4-脱氧氯代苯甲酸裂解酶的基因、编码对氨基苯甲酸合成酶 I 组份的基因和编码对氨基苯甲酸合成酶 II 组份的基因导入棒状杆菌而获得的转化体，能够以糖类为原料高效生产 4-ABA 或其盐类。
• Herbicidal compositions
  申请人：University of Durham

  公开号：US11266149B2

  公开（公告）日：2022-03-08

  The present invention relates to herbicidal compositions which comprise glyphosate or related compounds together with a further agent which is designed to enhance the effects of glyphosate or related compounds and/or reduce the amount of glyphosate or related compounds which is required for herbicidal effect. There is also provided a method of treating plants with a herbicidal composition according to the present invention.

  本发明涉及除草组合物，该组合物包括草甘膦或相关化合物以及旨在增强草甘膦或相关化合物效果和/或减少除草效果所需的草甘膦或相关化合物用量的另一种药剂。本发明还提供了一种用除草组合物处理植物的方法。