N-((2S,3R,4R,5S,6R)-2-(tert-butoxy)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)acetamide

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-((2S,3R,4R,5S,6R)-2-(tert-butoxy)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)acetamide
• 英文别名: N-[4,5-dihydroxy-6-(hydroxymethyl)-2-[(2-methylpropan-2-yl)oxy]oxan-3-yl]acetamide
• 化学式: C₁₂H₂₃NO₆
• 分子量: 277.31
• InChiKey: PXQDIFJAITZUPX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  108
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• LIPID CONTAINING FORMULATIONS
  申请人：MANOHARAN Muthiah

  公开号：US20120046478A1

  公开（公告）日：2012-02-23

  Compositions and methods useful in administering nucleic acid based therapies, for example association complexes such as liposomes and lipoplexes are described.

  本文描述了在进行核酸基础治疗时有用的组合物和方法，例如关联复合物，如脂质体和脂质复合物。
• Glucose conjugates of triptolide, analogs and uses thereof
  申请人：The Johns Hopkins University

  公开号：US10695319B2

  公开（公告）日：2020-06-30

  Provided are compounds generated by conjugation of triptolide with glucose to form glucose-triptolide conjugates, provides compounds with effective anti-proliferative activity and improved tolerability as compared to naturally occurring triptolide compounds.

  本研究提供了通过三苯内酯与葡萄糖共轭形成葡萄糖-三苯内酯共轭物而生成的化合物，与天然存在的三苯内酯化合物相比，这些化合物具有有效的抗增殖活性和更好的耐受性。
• Inhibition of galectin 3 binding to the airway epithelial surface to treat or prevent septic shock resulting from influenza and subsequent pneumococcal pneumonia infection
  申请人：Vasta Gerardo

  公开号：US10905702B2

  公开（公告）日：2021-02-02

  Galectin 3 inhibitors and methods for treating sepsis using the same are provided herein.

  本文提供了凝集素 3 抑制剂和使用凝集素 3 抑制剂治疗败血症的方法。
• GLUCOSE CONJUGATES OF TRIPTOLIDE, ANALOGS AND USES THEREOF
  申请人：The Johns Hopkins University

  公开号：US20190038596A1

  公开（公告）日：2019-02-07

  Provided are compounds generated by conjugation of triptolide with glucose to form glucose-triptolide conjugates, provides compounds with effective anti-proliferative activity and improved tolerability as compared to naturally occurring triptolide compounds.
• Inhibition of Galectin 3 Binding to the Airway Epithelial Surface to Treat or Prevent Septic Shock Resulting From Influenza and Subsequent Pneumococcal Pneumonia Infection
  申请人：VASTA Gerardo

  公开号：US20190142853A1

  公开（公告）日：2019-05-16

  Galectin 3 inhibitors and methods for treating sepsis using the same are provided herein.