6-(Hydroxymethyl)cyclohexane-1,2,3,4,5-pentol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 6-(Hydroxymethyl)cyclohexane-1,2,3,4,5-pentol
• 化学式: C₇H₁₄O₆
• 分子量: 194.18
• InChiKey: QFYQIWDMMSKNFF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  121
• 氢给体数：
  6
• 氢受体数：
  6

文献信息

• METHOD FOR PRODUCING CDNA AND RNA CHAINS AND NUCLEOTIDE-IMMOBILIZED SUPPORT
  申请人：Sumitomo Bakelite Company, Ltd.

  公开号：EP1930422A1

  公开（公告）日：2008-06-11

  A method of synthesizing a cDNA chain using an insoluble carrier having on the surface thereof a polymer substance containing a first unit having a group derived from a phosphoric ester composing the hydrophilic portion of phospholipid, and a second unit having a group derived from carboxylic acid having an electron-attractive substituent bound to a carbonyl group, which includes immobilizing a polynucleotide for DNA elongation; bringing a solution containing an RNA fragment, nucleotide monomers, and a reverse transcriptase or an enzyme having polymerase activity into contact with the surface of the insoluble carrier; and allowing the polynucleotide for DNA elongation immobilized on the surface of the carrier to elongate using the RNA fragment contained in the solution as a template, to thereby form a single-strand cDNA.

  一种使用不溶性载体合成 cDNA 链的方法，该不溶性载体的表面具有一种高分子物质，该高分子物质的第一单元具有来自构成磷脂亲水部分的磷酸酯的基团，第二单元具有来自具有与羰基结合的引电子取代基的羧酸的基团，该方法包括固定用于 DNA 延长的多核苷酸；将含有 RNA 片段、核苷酸单体和逆转录酶或具有聚合酶活性的酶的溶液与不溶性载体的表面接触；并使固定在载体表面的 DNA 延伸多核苷酸以溶液中所含的 RNA 片段为模板延伸，从而形成单链 cDNA。