trans-3-ethoxy-2-methylcyclobutanone | 1182843-02-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: trans-3-ethoxy-2-methylcyclobutanone
• 英文别名: rel-(2R,3S)-3-Ethoxy-2-methylcyclobutanone；(2S,3R)-3-ethoxy-2-methylcyclobutan-1-one
• CAS: 1182843-02-2
• 化学式: C₇H₁₂O₂
• 分子量: 128.171
• InChiKey: ZIFOLMFMBZRDLS-IYSWYEEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  丙酰氯 、 乙烯基乙醚 在 N,N-二异丙基乙胺 作用下， 反应 2.0h， 生成 trans-3-ethoxy-2-methylcyclobutanone 、 cis-3-ethoxy-2-methylcyclobutanone
  参考文献：
  名称：

  An efficient procedure for preparation of 2-monoalkyl or 2-monoaryl-3-ethoxycyclobutanones

  摘要：

  Optimized reaction conditions for the preparation of various 2-monosubstituted 3-ethoxycyclobutanones are described. 2-Monoalkyl 3-ethoxycyclobutanones were efficiently prepared by the reaction of the corresponding carboxylic acid chlorides and an excess amount of ethyl vinyl ether in the presence of diisopropylethylamine at 90 degrees C in a sealed tube. 2-Monoaryl 3-ethoxycyclobutanones were prepared by using 2,6-lutidine as a base in the above-mentioned procedure. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.05.031

文献信息

• An efficient procedure for preparation of 2-monoalkyl or 2-monoaryl-3-ethoxycyclobutanones
  作者：Jun-ichi Matsuo、Ryosuke Okuno、Kosuke Takeuchi、Mizuki Kawano、Hiroyuki Ishibashi

  DOI：10.1016/j.tetlet.2010.05.031

  日期：2010.7

  Optimized reaction conditions for the preparation of various 2-monosubstituted 3-ethoxycyclobutanones are described. 2-Monoalkyl 3-ethoxycyclobutanones were efficiently prepared by the reaction of the corresponding carboxylic acid chlorides and an excess amount of ethyl vinyl ether in the presence of diisopropylethylamine at 90 degrees C in a sealed tube. 2-Monoaryl 3-ethoxycyclobutanones were prepared by using 2,6-lutidine as a base in the above-mentioned procedure. (C) 2010 Elsevier Ltd. All rights reserved.