7-Oxabicyclo(4.1.0)hept-3-ene-2,5-dione, 3-methyl- | 15254-70-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 7-Oxabicyclo(4.1.0)hept-3-ene-2,5-dione, 3-methyl-
• 英文别名: 3-methyl-7-oxabicyclo[4.1.0]hept-3-ene-2,5-dione
• CAS: 15254-70-3
• 化学式: C₇H₆O₃
• 分子量: 138.12
• InChiKey: QMPGHDQKVHABLV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  46.7
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• 合成によるセオブロキシドの製造方法
  申请人：独立行政法人 科学技術振興機構

  公开号：JP2004182633A

  公开（公告）日：2004-07-02

  【課題】セオブロキシド（３，６−ジヒドロキシ−４，５−エポキシ−１−メチルシクロヘキセン）の工業的大量入手方法として、簡単な工程で、安全な、化学合成による製造方法を提供すること。【解決手段】メチルヒドロキノンを、酸化してｐ−トルキノンを製造し、該ｐ−トルキノンをエポキシ化して、４，５−エポキシ−１−メチルシクロヘキセン−３，６−ジオンを製造する。更に、該４，５−エポキシ−１−メチルシクロヘキセン−３，６−ジオンを還元して、セオブロキシド（３，６−ジヒドロキシ−４，５−エポキシ−１−メチルシクロヘキセン）を製造する。更に、本発明は、上記ｐ−トルキノンをエポキシ化する際に副生され副生物をシクロペンタジエンを用いてＤｉｅｌｓ−Ａｌｄｅｒ反応を行い、反応物をクロマトグラフィーを用いて分離する精製方法を含む。

  [问题]作为一种工业化批量获取可可碱（3,6-二羟基-4,5-环氧-1-甲基环己烯）的方法，其工艺简单且安全、将提供化学合成的生产方法。甲基氢醌经氧化生成对甲苯醌，对甲苯醌再经环氧化生成 4,5-环氧-1-甲基环己烯-3-酮。甲基环己烯-3,6-二酮。此外，4,5-环氧-1-甲基环己烯-3,6-二酮还会被还原成可可碱（3,6-二羟基-4,5-环氧-1-甲基环己烯-3,6-二酮）。-4,5-环氧-1-甲基环己烯）。此外，本发明还包括一种纯化方法，即使用环戊二烯对上述对甲苯醌环氧化反应的副产物进行 Diels-Alder 反应，并使用色谱法分离反应物。
• Macrophage activation inhibitor
  申请人：Umezawa Kazuo

  公开号：US20070142465A1

  公开（公告）日：2007-06-21

  A compound represented by the following general formula (1): wherein R 1 represents a hydrogen atom or a C2 to C4 alkanoyl group and R 2 represents a group represented by the following formula (A), (B), (C), (D), (E), (F), or (G): wherein R 3 represents a C1 to C4 alkyl group can inhibit macrophage activation. Accordingly, a macrophage activation inhibitor containing a compound represented by the general formula (1) or its pharmacologically acceptable salt as an active ingredient is useful as an agent for preventing, improving, or treating a disease resulting from infection with pathogens such as a bacterium and a virus.
• Agent for Inhibiting Bolting Induction and/or Floral-Bud Differentiation in Plants
  申请人：Yoshihara Teruhiko

  公开号：US20070244009A1

  公开（公告）日：2007-10-18

  The present invention provides an agent for inhibiting bolting induction and/or floral-bud differentiation in plants and the method for inhibiting the bolting induction and/or floral differentiation of plants using the above-mentioned agent for inhibiting bolting induction and/or floral-bud differentiation in plants. Theobroxide or its analog is used as the agent for inhibiting bolting induction and/or floral-bud differentiation in plants. The agent for inhibiting bolting induction and/or floral-bud differentiation in plants is applied under a plant's bolting induction and/or floral differentiation condition, and controls the bolting induction and/or floral differentiation of the plant. In the case of long-day plants, such as spinach, wherein their bolting induction and floral differentiation occur under a long-day condition, spraying on plants is done under the corresponding long-day condition. The agent for inhibiting bolting induction and/or floral-bud differentiation in plants can be applied to plants by an application method such as foliar spray.