4-epi-L-vancosamine | 74966-73-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-epi-L-vancosamine
• 英文别名: L-4-epi-vancosamine；4-epi-vancosamine；3-Amino-2,3,6-trideoxy-3-c-methyl-l-arabino-hexopyranose；(4S,5R,6S)-4-amino-4,6-dimethyloxane-2,5-diol
• CAS: 74966-73-7
• 化学式: C₇H₁₅NO₃
• 分子量: 161.201
• InChiKey: OIJZDPGKNVKVBL-SHXUCJRQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  75.7
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-epi-L-vancosamine 在 吡啶 作用下， 生成
  参考文献：
  名称：

  含有支链糖4-表-L-vancosamine的蒽环类抗生素的新类似物的合成

  摘要：

  已经制备了含有支链氨基糖4-表-L-vancosamine的蒽环类抗生素的新型半合成类似物。

  DOI：

  10.1016/s0040-4039(00)97739-6

文献信息

• Derivatives of Dihydroxypyrrolidine as Anti-Cancer Compounds
  申请人：EPFL Ecole Polytechnique Fédérale de Lausanne

  公开号：EP2067771A1

  公开（公告）日：2009-06-10

  The present invention relates to derivatives of dihydroxypyrrolidine useful in the treatment of cancer. The invention further relates to a process for making the compounds. The compounds are inhibitors of α mannosidase, and possibly, also inhibit nicotinamide phosphoribosyl transferase.

  本发明涉及一种二羟基吡咯烷衍生物，可用于癌症治疗。该发明还涉及一种制备该化合物的方法。该化合物是α甘露糖苷酶的抑制剂，可能也抑制烟酰胺磷酸核糖转移酶。
• A Practical Method for the Stereoselective Generation of β-2-Deoxy Glycosyl Phosphates
  作者：Markus Oberthür、Catherine Leimkuhler、Daniel Kahne

  DOI：10.1021/ol049187f

  日期：2004.8.1

  beta-2-Deoxy sugar nucleotides are substrates used by a variety of glycosyltransferases (Gtfs). We have developed a chemical route to synthesize beta-2-deoxy sugar phosphates that starts from a-glycosyl chlorides. Our approach reliably provides access to a range of NDP beta-2-deoxy sugars essential for studying glycosyltransferases involved in the synthesis of biologically active natural products.
• OLSUFEVA, E. N.;BAKINOVSKIJ, L. V.;PREOBRAZHENSKAYA, M. N.;DE, KLERK EH.;+, BIOORGAN. XIMIYA, 17,(1991) N, S. 548-555
  作者：OLSUFEVA, E. N.、BAKINOVSKIJ, L. V.、PREOBRAZHENSKAYA, M. N.、DE, KLERK EH.、+

  DOI：——

  日期：——
• Synthesis of novel analogues of anthracycline antibiotics containing a branched-chain sugar 4-epi-L-vancosamine
  作者：Eugenya N. Olsufyeva、Leon V. Backinowsky

  DOI：10.1016/s0040-4039(00)97739-6

  日期：1990.1

  Novel semisynthetic analogues of anthracycline antibiotics containing a branched aminosugar 4-epi-L-vancosamine have been prepared.

  已经制备了含有支链氨基糖4-表-L-vancosamine的蒽环类抗生素的新型半合成类似物。