1-(3,8-Dimethyl-1,3a,4,5,6,7-hexahydroazulen-5-yl)ethanone

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(3,8-Dimethyl-1,3a,4,5,6,7-hexahydroazulen-5-yl)ethanone
• 化学式: C₁₄H₂₀O
• 分子量: 204.31
• InChiKey: RLXMQOKUFPBVGV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• Combination therapy for treatment of patients with neurological disorders and cerebral infarction
  申请人：Moleac Pte Ltd.

  公开号：EP2508191A1

  公开（公告）日：2012-10-10

  The present invention provides compositions and methods of treating a patient having a condition selected from the group of cerebral stroke, heart stroke, neurodegenerative diseases, brain or nervous system trauma, or neuroplasticity wherein the composition comprises: (i) at least 4, 5, 6, 7, 8, 9, 10, 11, 12, 13 or 14 of: Radix Astragali (milkvetch root or Huang Qi); Rhizoma Salviae Miltiorrhizae root (red sage or Dan Shen); Radix Paeoniae Rubra (red peony or chi shao); Ligusticum Chuanxiong (Chuan Xiong); Rhizoma Notoginseng (Sanqi); Odoriferous Rosewood (Jiang Xiang); Scorpion (Quan Xie); Radix Polygalae (Yuan Zhi); Grassleaf sweetflag (Shi Changpu); Leech (Hirudo or Shuizhi); Ground beetle (Tu Bie Chong); Cow bezoar (calculus Bovis artifactus or Rengong Niuhuang); Gambirplant (ramulus uncariae cum uncis or Gou teng); and (ii) an agent used in Western medicine.

  本发明提供了治疗选自脑中风、心脏中风、神经退行性疾病、脑或神经系统创伤或神经可塑性疾病的患者的组合物和方法，其中组合物包括：(i) 至少4、5、6、7、8、9、10、11、12、13或14种：黄芪；丹参；赤芍；川芎；三七；紫檀；全蝎；蝎子（全蝎）；远志（远志）；草叶甘草（石菖蒲）；水蛭（葫芦或水芝）；地鳖虫（土鳖虫）；牛黄（牛黄结石或人参牛黄）；钩藤（钩藤或钩藤瘤）；以及 (ii) 西药中使用的制剂。
• EP1993580A1
  申请人：——

  公开号：EP1993580A1

  公开（公告）日：2008-11-26
• Combination Therapy for Treatment of Patients with Neurological Disorders and Cerebral Infarction
  申请人：Shi Xuemin

  公开号：US20090162459A1

  公开（公告）日：2009-06-25

  The present invention provides compositions and methods of treating a patient having a condition selected from the group of cerebral stroke, heart stroke, neurodegenerative diseases, brain or nervous system trauma, or neuroplasticity wherein the composition comprises: (i) at least 4, 5, 6, 7, 8, 9, 10, 11, 12, 13 or 14 of: Radix Astragali (milkvetch root or Huang Qi); Rhizoma Salviae Miltiorrhizae root (red sage or Dan Shen); Radix Paeoniae Rubra (red peony or chi shao); Ligusticum Chuanxiong (Chuan Xiong); Rhizoma Notoginseng (Sanqi); Odoriferous Rosewood (Jiang Xiang); Scorpion (Quan Xie); Radix Polygalae (Yuan Zhi); Grassleaf sweetflag (Shi Changpu); Leech (Hirudo or Shuizhi); Ground beetle (Tu Bie Chong); Cow bezoar (calculus Bovis artifactus or Rengong Niuhuang); Gambirplant (ramulus uncariae cum uncis or Gou teng); and (ii) an agent used in Western medicine.
• [EN] COMBINATION THERAPY FOR TREATMENT OF PATIENTS WITH NEUROLOGICAL DISORDERS AND CEREBRAL INFARCTION<br/>[FR] THÉRAPIE COMBINÉE POUR LE TRAITEMENT DE PATIENTS PRÉSENTANT DES TROUBLES NEUROLOGIQUES ET UN INFARCTUS CÉRÉBRAL
  申请人：MOLEAC PTE LTD

  公开号：WO2007106049A1

  公开（公告）日：2007-09-20

  [EN] The present invention provides compositions and methods of treating a patient having a condition selected from the group of cerebral stroke, heart stroke, neurodegenerative diseases, brain or nervous system trauma, or neuroplasticity wherein the composition comprises: (i) at least 4, 5, 6, 7, 8, 9, 10, 11, 12, 13 or 14 of: Radix Astragali (milkvetch root or Huang Qi); Rhizoma Salviae Miltiorrhizae root (red sage or Dan Shen); Radix Paeoniae Rubra (red peony or chi shao); Ligusticum Chuanxiong (Chuan Xiong); Rhizoma Notoginseng (Sanqi); Odoriferous Rosewood (Jiang Xiang); Scorpion (Quan Xie); Radix Polygalae (Yuan Zhi); Grassleaf sweetflag (Shi Changpu); Leech (Hirudo or Shuizhi); Ground beetle (Tu Bie Chong); Cow bezoar (calculus Bovis artifactus or Rengong Niuhuang); Gambirplant (ramulus uncariae cum uncis or Gou teng); and (ii) an agent used in Western medicine.
  [FR] La présente invention concerne des compositions et des procédés de traitement d'un patient présentant une condition choisie dans le groupe constitué par l'accident vasculaire cérébral, la crise cardiaque, les maladies neurodégénératives, les traumatismes du cerveau ou du système nerveux ou la neuroplasticité, ladite composition comprenant : (i) au moins 4, 5, 6, 7, 8, 9, 10, 11, 12, 13 ou 14 agents parmi : - Radix astragali (racine d'astragale ou Huang Qi) - Radix salviae miltiorrhizae (racine de sauge rouge ou Dan Shen) - Radix paeoniae rubra (racine de pivoine rouge ou Chi Shao) - Ligusticum chuanxiong (Chuan Xiong) - Radix notoginseng (San Qi) - Dalbergia odorifera (Jiang Xiang) - Scorpion (Quan Xie) - Radix polygalae (Yuan Zhi) - Jonc à feuilles de graminées (Shi Chang Pu) - Sangsue (Hirudo ou Shui Zhi) - Eupolyphaga seu opisthoplatia (Tu Bie C