1-Amino-6-hydroxy-16--7.10-dioxo-6,11-diaza-hexadecan | 252325-60-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 1-Amino-6-hydroxy-16--7.10-dioxo-6,11-diaza-hexadecan
• 英文别名: Deferoxamine mesilate impurity B [EP impurity]；N-[5-[acetyl(hydroxy)amino]pentyl]-N'-(5-aminopentyl)-N'-hydroxybutanediamide
• CAS: 252325-60-3
• 化学式: C₁₆H₃₂N₄O₅
• 分子量: 360.454
• InChiKey: RSSRKKMWVNCQBZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  25
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.81
• 拓扑面积：
  136
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  1-Amino-6-hydroxy-16--7.10-dioxo-6,11-diaza-hexadecan 在 platinum(IV) oxide ammonium hydroxide 、 硫酸 、 氢气 作用下， 反应 20.0h， 生成 4-((5-aminopentyl)amino)-4-oxobutanoic acid
  参考文献：
  名称：

  Stoffwechselprodukte von Mikroorganismen。216. Mitteilung。Isolierung，合成和合成Ferrioxamin H † ‡

  摘要：

  微生物的代谢产物。216.亚铁胺H的分离，结构与合成

  DOI：

  10.1002/hlca.19820650617
• 作为产物：
  描述：

  1-Carbobenzoxyamino-5-(N-succinyl-hydroxylamino)-pentan 在 palladium on activated charcoal 氢气 作用下， 以 甲醇 、 乙酸酐 为溶剂， 反应 5.0h， 生成 1-Amino-6-hydroxy-16--7.10-dioxo-6,11-diaza-hexadecan
  参考文献：
  名称：

  Stoffwechselprodukte von Actinomyceten。36. Mitteilung。黚死SYNTHESE DER铁草胺乙UND d 1

  摘要：

  天然微生物生长因子铁氧嘧啶B和D 1已通过反应顺序ⅢXI合成。

  DOI：

  10.1002/hlca.19620450228

文献信息

• Reverse Biosynthesis: Generating Combinatorial Pools of Drug Leads from Enzyme-Mediated Fragmentation of Natural Products
  作者：Tomas Richardson-Sanchez、William Tieu、Rachel Codd

  DOI：10.1002/cbic.201600636

  日期：2017.2.16

  desferrioxamine B (1) gave a pool of catabolites; subsequent derivatisation yielded a 5‐lipoxygenase inhibitor. This top‐down approach to generate new drug leads from a natural product, “reverse biosynthesis”, provides a new perspective on natural products as a resource for drug discovery.

  建设性破坏：天然产物去铁草胺B（1）的酶介导裂解产生大量的分解代谢产物。随后的衍生化产生了5-脂氧合酶抑制剂。这种从天然产物“逆向生物合成”产生新药线索的自上而下的方法为将天然产物作为发现药物的资源提供了新的视角。
• ZIRCONIUM-RADIOLABELED, CYSTEINE ENGINEERED ANTIBODY CONJUGATES
  申请人：Gill Herman

  公开号：US20100111856A1

  公开（公告）日：2010-05-06

  Antibodies are engineered by replacing one or more amino acids of a parent antibody with non cross-linked, highly reactive cysteine amino acids. Antibody fragments may also be engineered with one or more cysteine amino acids to form cysteine engineered antibody fragments (ThioFab). Methods of design, preparation, screening, and selection of the cysteine engineered antibodies are provided. Cysteine engineered antibodies (Ab) are conjugated with one or more zirconium complex (Z) labels through a linker (L) to form cysteine engineered zirconium-labeled antibody conjugates having Formula I: Ab-(L-Z) p I where p is 1 to 4. Imaging methods and diagnostic uses for zirconium-radiolabeled, cysteine engineered antibody conjugate compositions are disclosed.

  抗体是通过将一个或多个亲缘抗体的氨基酸替换为非交联、高反应性的半胱氨酸氨基酸来设计的。抗体片段也可以通过引入一个或多个半胱氨酸氨基酸来设计半胱氨酸工程抗体片段（ThioFab）。提供了设计、制备、筛选和选择半胱氨酸工程抗体的方法。半胱氨酸工程抗体（Ab）通过连接剂（L）与一个或多个锆配合物（Z）标记结合，形成具有公式I的半胱氨酸工程锆标记抗体结合物：Ab-（L-Z）pI，其中p为1至4。揭示了锆放射标记、半胱氨酸工程抗体结合物组合物的成像方法和诊断用途。
• Stoffwechselprodukte von Mikroorganismen 49. Mitteilung. Die Ferrioxamine A1, A2 und D2
  作者：W. Keller-Schierlein、P. Mertens、V. Prelog、A. Walser

  DOI：10.1002/hlca.19650480407

  日期：——

  AbstractThe structures of the ferrioxamines A1, A2, and D2, minor components of the sideramine mixtures from cultures of Streptomyces, have been determined by degradation and, in part, by synthesis. Whereas the previously investigated ferrioxamines B, D1, E, and G contain but a single basic component, 1‐amino‐5‐hydroxylaminopentane, the ferrioxamines A1, A2, and D2 contain in addition to this base its lower homologue, 1‐amino‐4‐hydroxylamino‐butane.
• USE OF MITOCHONDRIA-TARGETED ELECTRON SCAVENGERS AS ANTI-INFLAMMATORY AGENTS
  申请人：Fink Mitchell P.

  公开号：US20090042808A1

  公开（公告）日：2009-02-12

  Provided herein are methods for using mitochondria-targeted electron scavengers as anti-inflammatory agents. The mitochondria-targeted electron scavenger comprises a free radical-scavenging group covalently linked to a mitochondria-targeting group derived from a hemigramicidin moiety. The mitochondria-targeted electron scavenger can be used to treat medical conditions associated with acute or chronic inflammation.
• BICYCLIC PEPTIDE LIGANDS WITH DETECTABLE MOIETIES AND USES THEREOF
  申请人：BicycleRD Limited

  公开号：US20210079045A1

  公开（公告）日：2021-03-18

  The present invention provides compounds, compositions thereof, and methods of using the same.