3-(3-bromopropyl)pyrrole | 117270-94-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 3-(3-bromopropyl)pyrrole
• 英文别名: 3-(3-bromopropyl)-1H-pyrrole
• CAS: 117270-94-7
• 化学式: C₇H₁₀BrN
• 分子量: 188.067
• InChiKey: XMKYZIFLGYJVPU-UHFFFAOYSA-N

物化性质

• 沸点：
  244.6±15.0 °C(Predicted)
• 密度：
  1.443±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  15.8
• 氢给体数：
  1
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  吡啶 、 3-(3-bromopropyl)pyrrole 在 silver tetrafluoroborate 作用下， 生成 1-(3-pyrrol-3-ylpropyl)pyridinium tetrafluoroborate
  参考文献：
  名称：

  Polypyrrole-based anion-exchange polymers

  摘要：

  The preparation and electrochemistry of two polypyrroles with cationic substituents in the 3-Position, and a precursor alkyl bromide substituted polymer, are reported. The electrochemical and ion-exchange properties of the new cationic polymers are similar to those of a previously reported N-substituted analogue. However, their lower redox potentials (ca. -0.1 V vs SSCE) mean that they become conductive at less oxidizing potentials. This is shown to be advantageous in the catalysis of ascorbate oxidation. The enhanced conductivity at low potentials also greatly accelerates the electrochemistry of electrostatically bound ferrocyanide. Surprisingly, the maximum conductivity of the new 3-substituted cationic polymers is lower than that of the N-substituted analogue. Poly[3-(3-bromopropyl)pyrrole] and cationic copolymers formed by its partial reaction with trimethylamine were used to probe the origin of this difference. Swelling of the polymers with electrolyte solution and associated morphological changes appear to be important factors.

  DOI：

  10.1021/j100192a074
• 作为产物：
  描述：

  1-(三异丙基甲硅烷基)吡咯 在 N-溴代丁二酰亚胺(NBS) 作用下， 以 四氢呋喃 为溶剂， 以92%的产率得到3-(3-bromopropyl)pyrrole
  参考文献：
  名称：

  Polypyrrole-based anion-exchange polymers

  摘要：

  The preparation and electrochemistry of two polypyrroles with cationic substituents in the 3-Position, and a precursor alkyl bromide substituted polymer, are reported. The electrochemical and ion-exchange properties of the new cationic polymers are similar to those of a previously reported N-substituted analogue. However, their lower redox potentials (ca. -0.1 V vs SSCE) mean that they become conductive at less oxidizing potentials. This is shown to be advantageous in the catalysis of ascorbate oxidation. The enhanced conductivity at low potentials also greatly accelerates the electrochemistry of electrostatically bound ferrocyanide. Surprisingly, the maximum conductivity of the new 3-substituted cationic polymers is lower than that of the N-substituted analogue. Poly[3-(3-bromopropyl)pyrrole] and cationic copolymers formed by its partial reaction with trimethylamine were used to probe the origin of this difference. Swelling of the polymers with electrolyte solution and associated morphological changes appear to be important factors.

  DOI：

  10.1021/j100192a074

文献信息

• Substituted anilinic piperidines as MCH selective antagonists
  申请人：Marzabadi R. Mohammad

  公开号：US20070043080A1

  公开（公告）日：2007-02-22

  This invention is directed to compounds which are selective antagonists for melanin concentrating hormone-1 (MCH1) receptors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of the compound of the invention and a pharmaceutically acceptable carrier. This invention provides a pharmaceutical composition made by combining a therapeutically effective amount of the compound of this invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of the compound of the invention and a pharmaceutically acceptable carrier.

  本发明涉及选择性拮抗黑色素浓集激素-1（MCH1）受体的化合物。本发明提供了一种药物组合物，包括本发明化合物的治疗有效量和药学上可接受的载体。本发明提供了一种由本发明化合物的治疗有效量和药学上可接受的载体组成的药物组合物。本发明还提供了一种制备药物组合物的方法，包括将本发明化合物的治疗有效量和药学上可接受的载体组合。
• Stefan, Klaus-Peter; Schuhmann, Wolfgang; Parlar, Harun, Chemische Berichte, 1989, vol. 122, p. 169 - 174
  作者：Stefan, Klaus-Peter、Schuhmann, Wolfgang、Parlar, Harun、Korte, Friedhelm

  DOI：——

  日期：——
• STEFAN, KLAUS-PETER;SCHUHMANN, WOLFGANG;PARLAR, HARUN;KORTE, FRIEDHELM, CHEM. BER., 122,(1989) N, C. 169-174
  作者：STEFAN, KLAUS-PETER、SCHUHMANN, WOLFGANG、PARLAR, HARUN、KORTE, FRIEDHELM

  DOI：——

  日期：——
• SUBSTITUTED ANILINIC PIPERIDINES AS MCH SELECTIVE ANTAGONISTS
  申请人：Synaptic Pharmaceutical Corporation

  公开号：EP1411942A1

  公开（公告）日：2004-04-28
• EP1411942A4
  申请人：——

  公开号：EP1411942A4

  公开（公告）日：2005-01-26