Benzyl N-acetylglucosamine

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Benzyl N-acetylglucosamine
• 英文别名: N-[4,5-dihydroxy-6-(hydroxymethyl)-2-phenylmethoxyoxan-3-yl]acetamide
• 化学式: C₁₅H₂₁NO₆
• mdl: MFCD00359886
• 分子量: 311.33
• InChiKey: SKOZFDIGKDPQBO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.533
• 拓扑面积：
  108
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• [EN] MONOSACCHARIDE PHOSPHORAMIDATE PRODRUGS<br/>[FR] PROMÉDICAMENTS À BASE DE PHOSPHORAMIDATE DE MONOSACCHARIDE
  申请人：CERECOR INC

  公开号：WO2019118486A1

  公开（公告）日：2019-06-20

  The present disclosure provides monosaccharide phosphoramidate prodrugs of monosaccharide monophosphates. The present disclosure further provides methods of treating diseases of conditions such as congenital disorders of glycosylation comprising administering the monosaccharide phosphoramidate prodrugs of the present disclosure to a patient in need thereof.

  本公开提供了单糖磷酰胺酯前药，用于单糖单磷酸。本公开还提供了治疗糖基化先天性疾病等疾病或症状的方法，包括向需要的患者施用本公开的单糖磷酰胺酯前药。
• Muramyl peptide derivative compound, synthesis and uses thereof
  申请人：BHARAT BIOTECH INTERNATIONAL LIMITED

  公开号：US10576147B2

  公开（公告）日：2020-03-03

  The invention relates to novel Muramyl Dipeptide (MDP) derivative compound of structural Formula-VIII, a process for synthesis, intermediates used in the synthesis and use thereof; wherein R1 and R2 both are hydrogen; or R1 is hydrogen and R2 is alkyl or aryl; or R1 is alkyl or aryl and R2 is hydrogen; or R1 and R2 both are alkyl or aryl (same or different groups); wherein alkyl group constitute C1-C6 alkyl or higher (both linear and branched) with or without heteroatoms; and aryl group constitute phenyl, substituted phenyl, heteraryl, arylalkyl and polynuclear aromatics. These compounds possess excellent pharmacological properties, in particular immunomodulating properties for use as adjuvant in vaccine formulations. These compounds are, particularly useful as adjuvants in vaccines.

  本发明涉及结构式-VIII 的新型 Muramyl 二肽 (MDP) 衍生物化合物、合成工艺、合成中使用的中间体及其用途； 其中 R1 和 R2 均为氢；或 R1 为氢，R2 为烷基或芳基；或 R1 为烷基或芳基，R2 为氢；或 R1 和 R2 均为烷基或芳基（相同或不同基团）；其中烷基为 C1-C6 烷基或更高的烷基（包括直链和支链），含或不含杂原子；芳基为苯基、取代苯基、杂芳基、芳烷基和多核芳烃。这些化合物具有优异的药理特性，特别是免疫调节特性，可用作疫苗制剂中的佐剂。这些化合物尤其可用作疫苗佐剂。
• Compositions, methods and treatments for inhibiting cell adhesion and virus binding and penetration
  申请人：TUMOREND, LLC

  公开号：US11203776B2

  公开（公告）日：2021-12-21

  Disclosed herein are glyco-decoy acceptor compositions that sidetrack or inhibit the activity of biosynthetic enzymes participating in synthesis of ligands binding at selectin, galectin and siglecs receptors; methods of their preparation and uses in drug discovery and in treatments of diseases.

  本文所公开的是糖化癸二酸受体组合物，这种组合物能旁路或抑制参与合成结合在选择素、galectin 和 siglecs 受体上的配体的生物合成酶的活性；它们的制备方法以及在药物发现和疾病治疗中的用途。
• COMPOSITIONS, METHODS AND TREATMENTS FOR INHIBITING CELL ADHESION AND VIRUS BINDING AND PENETRATION
  申请人：TUMOREND, LLC

  公开号：US20190017095A1

  公开（公告）日：2019-01-17

  Disclosed herein are glyco-decoy acceptor compositions that sidetrack or inhibit the activity of biosynthetic enzymes participating in synthesis of ligands binding at selectin, galectin and siglecs receptors; methods of their preparation and uses in drug discovery and in treatments of diseases.