申请人:WAYNE STATE UNIVERSITY
公开号:US20210107932A1
公开(公告)日:2021-04-15
The present disclosure relates to derivatives of neamine-based aminoglycoside antibacterial drugs modified in position C6′, C2′ and/or C5″. The modifications impart favorable properties regarding activity against ESKAPE pathogens, evasion of resistance traits and increased selectivity, enabling systemic use of the compounds.
本公开涉及对以奈阿霉素为基础的氨基糖苷抗菌药物进行的在C6'、C2'和/或C5''位置进行修饰的衍生物。这些修饰赋予了有利的特性,包括对ESKAPE病原体的活性、逃避抗药性特征以及增加选择性,从而使化合物能够进行全身应用。