Ranunculin | 644-69-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Ranunculin
• 英文别名: Rammculin；2-[[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]-2H-furan-5-one
• CAS: 644-69-9
• 化学式: C₁₁H₁₆O₈
• 分子量: 276.243
• InChiKey: TYWXNGXVSZRXNA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  126
• 氢给体数：
  4
• 氢受体数：
  8

文献信息

• Method of Improving Anticancer Effect of Pulsatillae Radix and a Composition Prepared by the Method
  申请人：Kim Song-Bae

  公开号：US20080268072A1

  公开（公告）日：2008-10-30

  The present invention relates to a composition enriched with 3-0-[O-α-L-rhamnopyranosyl-(1→2)-[0-β-D-glucopyranosyl-(1-→4)]-α-L-arabinopyranosyl]hederagenin (Code No. SB 365) of which antitumor activity is very strong by enzyme-reacting and extracting Pulsatillac radix.

  本发明涉及一种通过酶反应和从半夏根提取的，富含3-0-[O-α-L-鼠李糖苷基-(1→2)-[0-β-D-葡萄糖苷基-(1→4)]-α-L-阿拉伯糖苷基]齐墩果苷（代码号SB 365）的组合物，其抗肿瘤活性非常强。
• MEDICINE CONTAINING ANEMONIN AS EFFECTIVE COMPONENT FOR TREATING ASEPTIC INFLAMMATION
  申请人：Hu, Shiqing

  公开号：EP1252893A1

  公开（公告）日：2002-10-30

  The present invention discloses a medicament useful for treating aseptic inflammations, containing anemonin as an effective ingredient, and use of the anemonin compound in treating aseptic inflammations. The effective ingredient in the present medicament, anemonin, can be extracted and separated from natural plants containing anemonin or its precursor. The present invention also discloses a method for preparing anemonin extract. The present medicament can be formulated into preparations for oral administration, injection and topical application, especially liquid extract, plaster, suppository, liniment, and paint etc., which can be transdermally absorbed.

  本发明公开了一种用于治疗无菌性炎症的药剂，其中含有作为有效成分的右旋柠檬 素，以及该右旋柠檬素化合物在治疗无菌性炎症中的用途。本发明药物中的有效成分--右旋柠檬素，可以从含有右旋柠檬素或其前体的天然植物中提取和分离出来。本发明还公开了一种茴芹素提取物的制备方法。本发明的药物可配制成口服、注射和外用制剂，特别是液体提取物、膏药、栓剂、亚麻药和涂料等，可以透皮吸收。
• Use of hederagenin 3-0-alpha-L-rhamnopyranosyl(1-2[beta-D-glucopyranosyl(1-4)]-alpha-L-arabinopyranoside or an extract from pulsatillae radix containing the same as a therapeutic agent for solid tumors
  申请人：Kim, Song Bae

  公开号：EP1388542A1

  公开（公告）日：2004-02-11

  This invention relates to a use of hederagenin 3-O-α-L-rhamnopyranosyl((1→2)-[β-D-glucopyranosyl(1→4)]-α-L-arabinopyranoside or a Pulsatillae radix extract containing the same as a therapeutic agent for solid tumors.

  本发明涉及一种将hederagenin 3-O-α-L-rhamnopyranosyl((1→2)-[β-D-glucopyranosyl(1→4)]-α-L-arabinopyranoside或含有相同成分的白头翁提取物用作实体瘤治疗剂的用途。
• Methods, compositions and kits for treating a subject using a recombinant neutralizing binding protein
  申请人：TUFTS UNIVERSITY

  公开号：US10202441B2

  公开（公告）日：2019-02-12

  Methods, compositions and kits are provided for treating a subject exposed to or at risk for exposure to a disease agent using a pharmaceutical composition including at least one recombinant binding protein or a source of expression of the binding protein, wherein the binding protein neutralizes a disease agent that is a toxin, for example a Clostridium difficile toxin, a Shiga toxin, a ricin toxin, or an anthrax toxin.

  提供了使用包括至少一种重组结合蛋白或结合蛋白表达源的药物组合物治疗暴露于或有暴露于疾病病原体风险的受试者的方法、组合物和试剂盒，其中结合蛋白可中和属于毒素的疾病病原体，例如艰难梭菌毒素、志贺毒素、蓖麻毒素或炭疽毒素。
• Medicament for treating aseptic inflammations containing anemonin as effective component
  申请人：——

  公开号：US20030064117A1

  公开（公告）日：2003-04-03

  The present invention discloses a medicament useful for treating aseptic inflammations, containing anemonin as an effective ingredient, and use of an anemonin compound in treating aseptic inflammations. The effective ingredient in the present medicament, anemonin, can be extracted and separated from natural plants containing anemonin or its precursor. The present invention also discloses a method for preparing anemonin extract. The present medicament can be formulated into preparations for oral administration, injection and topical application, especially liquid extract, plaster, suppository, liniment, and paint etc., which can be transdermally absorbed.

  本发明公开了一种用于治疗无菌性炎症的药物，其中含有作为有效成分的知母素，以及知母素化合物在治疗无菌性炎症中的用途。本发明药物中的有效成分--右旋柠檬素，可以从含有右旋柠檬素或其前体的天然植物中提取和分离出来。本发明还公开了一种茴芹素提取物的制备方法。本发明的药物可配制成口服、注射和外用制剂，特别是液体提取物、膏药、栓剂、亚麻药和涂料等，可以透皮吸收。