Decin-(5)-saeure-(1)-methylester | 18937-73-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Decin-(5)-saeure-(1)-methylester
• 英文别名: Methyl dec-5-ynoate
• CAS: 18937-73-0
• 化学式: C₁₁H₁₈O₂
• 分子量: 182.263
• InChiKey: HJMVKBXUUOQBJS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  13
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  甲醇 、 5-癸炔酸 在 咪唑 、 碘 、 三苯基膦 作用下， 以 二氯甲烷 为溶剂， 反应 0.08h， 以89%的产率得到Decin-(5)-saeure-(1)-methylester
  参考文献：
  名称：

  Mild Method for the Selective Esterification of Carboxylic Acids Based on the Garegg−Samuelsson Reaction

  摘要：

  A mild method for the selective esterification of primary alcohols is described. The use of different phosphines, I-2, and imidazole allows the selective esterification: of a wide variety of acids with excellent results. The generation of a bulky phosphonitun-carboxylate salt as intermediate could justify the selectivity observed in this process. Additionally, amides also can be synthesized with use of this method.

  DOI：

  10.1021/jo102395c

文献信息

• KETONE DERIVATIVES AND MEDICINAL USE THEREOF
  申请人：TORAY INDUSTRIES, INC.

  公开号：EP0841063A1

  公开（公告）日：1998-05-13

  The present invention relates to ketone derivatives represented by the following formula and medical agents cotaining the ketone derivatives or pharmacologically acceptable salts thereof as an active ingredient, and in particular, relates to a hematopoietic agent; it is shown that the present invention increases blood cells, such as platelets, white blood cells, and red blood cells, and is effective in preventing and treating cytopenia caused by cancer chemotherapy, radiation therapy, and the like.

  本发明涉及下式所代表的酮衍生物和以酮衍生物或其药理学上可接受的盐作为活性成分的医用制剂，特别是涉及一种造血制剂；本发明可增加血小板、白细胞和红细胞等血细胞，对预防和治疗癌症化疗、放疗等引起的细胞减少症有效。
• Bohlmann,F. et al., Chemische Berichte, 1967, vol. 100, p. 3706 - 3715
  作者：Bohlmann,F. et al.

  DOI：——

  日期：——
• US6215016B1
  申请人：——

  公开号：US6215016B1

  公开（公告）日：2001-04-10
• Mild Method for the Selective Esterification of Carboxylic Acids Based on the Garegg−Samuelsson Reaction
  作者：Sara P. Morcillo、Luis Álvarez de Cienfuegos、Antonio J. Mota、José Justicia、Rafael Robles

  DOI：10.1021/jo102395c

  日期：2011.4.1

  A mild method for the selective esterification of primary alcohols is described. The use of different phosphines, I-2, and imidazole allows the selective esterification: of a wide variety of acids with excellent results. The generation of a bulky phosphonitun-carboxylate salt as intermediate could justify the selectivity observed in this process. Additionally, amides also can be synthesized with use of this method.