[5-Acetamido-3,4-diacetyloxy-6-(4-aminophenoxy)oxan-2-yl]methyl acetate

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [5-Acetamido-3,4-diacetyloxy-6-(4-aminophenoxy)oxan-2-yl]methyl acetate
• 英文别名: [5-acetamido-3,4-diacetyloxy-6-(4-aminophenoxy)oxan-2-yl]methyl acetate
• 化学式: C₂₀H₂₆N₂O₉
• 分子量: 438.4
• InChiKey: UGWNRSZZWMHTMU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  31
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  153
• 氢给体数：
  2
• 氢受体数：
  10

文献信息

• Immunodulating small molecules
  申请人：AyuVis Research, Inc.

  公开号：US11364253B2

  公开（公告）日：2022-06-21

  The present invention includes novel compositions and methods for treating comprising a compound with the Formula I: where n=0-5; X═NH, O, S, CH2; Y=Phenyl, a phenyl group substituted with at least one methyl, a phenyl group substituted with at least one nitro, a phenyl group substituted with at least one nitrogen, a phenyl group substituted with at least one boron, aryl, substituted aryl, heteroaryl, four to six membered cycloalkyl, four to six membered heterocycloalkyl; R═H, C(O)R2, SO2R2; R1═H, C(O)R2, SO2R2; R2=Ethyl, methyl, isopropyl, n-propyl, t-butyl, n-butyl, NH2, NR3R4, R3, R4=Ethyl, methyl, isopropyl, n-propyl, t-butyl, n-butyl, three to six membered cycloalkyl and Z═NH, O, S, CH2 or none, wherein the amount of the compound is selected to either inhibit or activate the immune response.

  本发明包括由式 I 化合物组成的新型组合物和治疗方法： 其中n＝0-5；X═NH，O，S，CH2；Y＝苯基，被至少一个甲基取代的苯基，被至少一个硝基取代的苯基，被至少一个氮取代的苯基，芳基，取代的芳基，杂芳基，四至六位环烷基，四至六位杂环烷基；R═H，C(O)R2，SO2R2； R1═H，C(O)R2，SO2R2；R2=Ethyl, methyl, isopropyl, n-propyl, t-butyl, n-butyl, NH2, NR3R4, R3, R4=Ethyl, methyl, isopropyl, n-propyl, t-butyl, n-butyl, three to six membered cycloalkyl and Z═NH, O, S, CH2 or none, 其中化合物的量被选择为抑制或激活免疫反应。