5-Hydroxy-4-methyl-7-oxabicyclo[4.1.0]hept-3-en-2-one

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-Hydroxy-4-methyl-7-oxabicyclo[4.1.0]hept-3-en-2-one
• 化学式: C₇H₈O₃
• 分子量: 140.14
• InChiKey: UNEAQOFRUAKQOI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  49.8
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Macrophage activation inhibitor
  申请人：Umezawa Kazuo

  公开号：US20070142465A1

  公开（公告）日：2007-06-21

  A compound represented by the following general formula (1): wherein R 1 represents a hydrogen atom or a C2 to C4 alkanoyl group and R 2 represents a group represented by the following formula (A), (B), (C), (D), (E), (F), or (G): wherein R 3 represents a C1 to C4 alkyl group can inhibit macrophage activation. Accordingly, a macrophage activation inhibitor containing a compound represented by the general formula (1) or its pharmacologically acceptable salt as an active ingredient is useful as an agent for preventing, improving, or treating a disease resulting from infection with pathogens such as a bacterium and a virus.