Paromomycin I

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Paromomycin I
• 英文别名: 5-amino-2-(aminomethyl)-6-[5-[3,5-diamino-2-[3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-hydroxycyclohexyl]oxy-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxyoxane-3,4-diol
• 化学式: C₂₃H₄₅N₅O₁₄
• 分子量: 615.6
• InChiKey: UOZODPSAJZTQNH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -8.7
• 重原子数：
  42
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  347
• 氢给体数：
  13
• 氢受体数：
  19

ADMET

毒理性

• 在妊娠和哺乳期间的影响

母乳喂养期间使用总结：目前没有关于母乳喂养期间使用巴龙霉素的临床信息。由于巴龙霉素口服吸收不良，它不太可能进入婴儿的血液循环或对哺乳婴儿产生任何不良反应。 对哺乳婴儿的影响：截至修订日期，没有找到相关的已发布信息。 对泌乳和母乳的影响：截至修订日期，没有找到相关的已发布信息。

◉ Summary of Use during Lactation:No information is available on the clinical use of paromomycin during breastfeeding. Because paromomycin is poorly absorbed orally, it is not likely to reach the bloodstream of the infant or cause any adverse effects in breastfed infants. ◉ Effects in Breastfed Infants:Relevant published information was not found as of the revision date. ◉ Effects on Lactation and Breastmilk:Relevant published information was not found as of the revision date.

来源:Drugs and Lactation Database (LactMed)

文献信息

• ANTIBACTERIAL 1,4,5-SUBSTITUTED AMINOGLYCOSIDE ANALOGS
  申请人：Linsell Martin

  公开号：US20080300199A1

  公开（公告）日：2008-12-04

  The present invention is directed to analogs of aminoglycoside compounds as well as their preparation and use as prophylactic or therapeutics against microbial infection.

  本发明涉及氨基糖苷化合物的类似物，以及它们的制备和用作预防或治疗微生物感染的药物。
• SYNTHESE DE NOUVEAUX DERIVES DE NEAMINE ET LEUR UTILISATION COMME AGENTS ANTIBACTERIENS
  申请人：Université Joseph Fourier

  公开号：EP2235031B1

  公开（公告）日：2017-07-26
• ANTIMICROBIAL 2-DEOXYSTREPTAMINE COMPOUNDS
  申请人：Hanessian Stephen

  公开号：US20080045468A1

  公开（公告）日：2008-02-21

  The present invention is directed to analogs of paromomycin having a variety of chemical functional groups attached at the 2″-O-position as well as their preparation and use as prophylactic or therapeutics against microbial infection.
• ANTIBACTERIAL 4,5-SUBSTITUTED AMINOGLYCOSIDE ANALOGS HAVING MULTIPLE SUBSTITUENTS
  申请人：Swayze Eric E.

  公开号：US20080293649A1

  公开（公告）日：2008-11-27

  The present invention is directed to analogs of aminoglycoside compounds as well as their preparation and use as prophylactic or therapeutics against microbial infection.
• CHIRAL SELECTORS FOR SEPARATING ENANTIOMERS OF A COMPOUND
  申请人：Peyrin Eric

  公开号：US20100144045A1

  公开（公告）日：2010-06-10

  The invention relates to the use of compounds as new chiral selectors for separating the optical or enantiomeric isomers of a compound, wherein the chiral selector comprises at least one compound of formula (I): and at least one metal ion, for example Cu 2+ , Ni 2+ , Zn 2+ , Cd 2+ or Co 2+ .