4-[4-[4-[3,5-Dihydroxy-6-(hydroxymethyl)-4-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-(hydroxymethyl)oxane-2,3,5-triol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-[4-[4-[3,5-Dihydroxy-6-(hydroxymethyl)-4-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-(hydroxymethyl)oxane-2,3,5-triol
• 化学式: C₃₀H₅₂O₂₆
• 分子量: 828.7
• InChiKey: UUQINGLDFWYORW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -9
• 重原子数：
  56
• 可旋转键数：
  13
• 环数：
  5.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  427
• 氢给体数：
  17
• 氢受体数：
  26

文献信息

• Vaccine against Klebsiella pneumoniae
  申请人：Idorsia Pharmaceuticals Ltd

  公开号：US11479574B2

  公开（公告）日：2022-10-25

  The present invention relates to a synthetic saccharide of general formula (I) that is related to Klebsiella pneumoniae serotype O1, O2, O2ac, and O8 O-polysaccharide and carbapenem-resistant Klebsiella pneumoniae ST258 O-polysaccharide and conjugate thereof. Said synthetic saccharide, said conjugate and pharmaceutical composition containing said synthetic saccharide or said conjugate are useful for prevention and/or treatment of diseases associated with Klebsiella pneumoniae. Furthermore, the synthetic saccharide of general formula (I) is useful as marker in immunological assays for detection of antibodies against Klebsiella pneumoniae bacteria.

  本发明涉及一种与肺炎克雷伯菌血清型O1、O2、O2ac和O8 O-多糖以及耐碳青霉烯类肺炎克雷伯菌ST258 O-多糖有关的通式（I）合成糖及其共轭物。所述合成糖、所述共轭物和含有所述合成糖或所述共轭物的药物组合物可用于预防和/或治疗与肺炎克雷伯氏菌相关的疾病。此外，通式（I）的合成糖苷可作为免疫学试验中的标记物，用于检测针对肺炎克雷伯氏菌的抗体。