(3aR,5S,6S,7R,7aR)-2-(ethylamino)-6,7-dihydroxy-N,N-dimethyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]thiazole-5-carboxamide | 1424256-20-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃
• 英文名称: (3aR,5S,6S,7R,7aR)-2-(ethylamino)-6,7-dihydroxy-N,N-dimethyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]thiazole-5-carboxamide
• 英文别名: (3aR,5S,6S,7R,7aR)-2-ethylimino-6,7-dihydroxy-N,N-dimethyl-1,3a,5,6,7,7a-hexahydropyrano[3,2-d][1,3]thiazole-5-carboxamide
• CAS: 1424256-20-1
• 化学式: C₁₁H₁₉N₃O₄S
• 分子量: 289.356
• InChiKey: BJEAVRXGLTWRDM-OPJPCFLTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  120
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  thiamet-G 在 sodium hypochlorite 、 2,2,6,6-四甲基哌啶氧化物 、 水 、 碳酸氢钠 、 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 N,N-二异丙基乙胺 、 potassium bromide 作用下， 以 四氢呋喃 、 二甲基亚砜 为溶剂， 生成 (3aR,5S,6S,7R,7aR)-2-(ethylamino)-6,7-dihydroxy-N,N-dimethyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]thiazole-5-carboxamide
  参考文献：
  名称：

  [EN] PYRANO [3, 2 - D] [1, 3] THIAZOLE AS GLYCOSIDASE INHIBITORS
  [FR] PYRANO[3,2-D][1,3]THIAZOLE FORMANT DES INHIBITEURS DE LA GLYCOSIDASE

  摘要：

  化合物的新颖结构如下（I），其中R1至R4和X的含义根据要求，是葡萄糖苷酶抑制剂，可用于治疗阿尔茨海默病。

  公开号：

  WO2013028715A1

文献信息

• [EN] GLYCOSIDASE INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS DE GLYCOSIDASES ET LEURS UTILISATIONS
  申请人：MERCK SHARP & DOHME

  公开号：WO2014100934A1

  公开（公告）日：2014-07-03

  The compounds with enhanced permeability for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds are provided. The methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc are also provided.

  提供了增强渗透性以选择性抑制糖苷酶的化合物，这些化合物的前药，以及包括这些化合物或其前药的药物组合物。还提供了治疗与O-GlcNA酶缺乏或过度表达、O-GlcNAc的积累或缺乏相关的疾病和紊乱的方法。
• [EN] GLYCOSIDASE INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS DE LA GLYCOSIDASE ET LEURS UTILISATIONS
  申请人：MERCK SHARP & DOHME

  公开号：WO2014105662A1

  公开（公告）日：2014-07-03

  The invention provides compounds with enhanced permeability for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc.

  该发明提供了具有增强渗透性的化合物，用于选择性抑制糖苷酶，这些化合物的前药，以及包括这些化合物或这些化合物的前药的药物组合物。该发明还提供了治疗与O-GlcNAcase缺乏或过度表达、O-GlcNAc的积累或缺乏相关的疾病和紊乱的方法。
• Pyrano[3,2-D][1,3]thiazole as glycosidase inhibitors
  申请人：Donnelly Marianne

  公开号：US20140243370A1

  公开（公告）日：2014-08-28

  Novel compounds of formula (I) wherein R 1 to R 4 and X have the meaning according to the claims, are glucosidase inhibitors, and can be employed, inter alia, for the treatment of Alzheimer's disease.

  公式（I）的新化合物，其中R1至R4和X的含义根据权利要求书中所述，是葡萄糖苷酶抑制剂，可用于治疗阿尔茨海默病等疾病。
• PYRANO [3, 2 - D][1, 3]THIAZOLE AS GLYCOSIDASE INHIBITORS
  申请人：Merck Patent GmbH

  公开号：EP2748171A1

  公开（公告）日：2014-07-02
• GLYCOSIDASE INHIBITORS AND USES THEREOF
  申请人：MEADWESTVACO PACKAGING SYSTEMS, LLC

  公开号：US20160194337A1

  公开（公告）日：2016-07-07

  A locking arrangement secures together first and second panels. The arrangement includes locking tabs ( 54, 56, 58 ) projecting from an end edge ( 64 ) of the first panel ( 12 ) and locking slits ( 50 a, 50 b, 50 c ) in the second panel ( 28 ). Each locking slit is provided for receiving a respective one of the locking tabs. The locking tabs and the locking slits are engageable by relative sliding movement with each other. At least one of the locking tabs and locking slits is configured to secure the first and second panels in a first overlapping position while at least another one of the locking tabs and locking slits is configured to secure the first and second panels in a second overlapping position.