6-Cyclopentyl-hexansaeure | 5763-59-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 6-Cyclopentyl-hexansaeure
• 英文别名: 2-cyclopentanehexanoic acid；6-Cyclopentylhexanoic acid
• CAS: 5763-59-7
• 化学式: C₁₁H₂₀O₂
• 分子量: 184.279
• InChiKey: YZLJCDLEUKPEFG-UHFFFAOYSA-N

物化性质

• 熔点：
  33-33.5 °C
• 沸点：
  133 °C(Press: 0.1 Torr)
• 密度：
  0.9518 g/cm3(Temp: 35 °C)

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  13
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6-Cyclopentyl-hexansaeure 、 苄胺 生成 N-Benzyl-6-cyclopentylhexanamid
  参考文献：
  名称：

  Garwood,R.F. et al., Journal of the Chemical Society. Perkin transactions I, 1973, p. 2714 - 2721

  摘要：

  DOI：
• 作为产物：
  描述：

  环戊烷丙醛 在 nickel(II) iodide 、 锰 、 正丁基锂 、 2,9-二甲基-4,7二苯基-1,10-菲啰啉 、 水 作用下， 以 四氢呋喃 、 正己烷 、 N,N-二甲基甲酰胺 为溶剂， 50.0 ℃ 、101.33 kPa 条件下， 反应 12.5h， 生成 6-Cyclopentyl-hexansaeure
  参考文献：
  名称：

  不饱和烃与 CO2 和水的位点选择性催化羧化

  摘要：

  描述了一种催化协议，该协议利用水作为正式氢化物源可靠地预测和控制 CO2 的位点选择性掺入到各种不饱和烃中。该平台为在温和条件下催化重新利用三种丰富的正交原料提供了机会。

  DOI：

  10.1021/jacs.7b07637

文献信息

• Active agent transport systems
  申请人：Emisphere Technologies, Inc.

  公开号：US20010039258A1

  公开（公告）日：2001-11-08

  Methods for transporting a biologically active agent across a cellular membrane or a lipid bilayer. A first method includes the steps of: (a) providing a biologically active agent which can exist in a native conformational state, a denatured conformational state, and an intermediate conformational state which is reversible to the native state and which is conformationally between the native and denatured states; (b) exposing the biologically active agent to a complexing perturbant to reversibly transform the biologically active agent to the intermediate state and to form a transportable supramolecular complex; and (c) exposing the membrane or bilayer to the supramolecular complex, to transport the biologically active agent across the membrane or bilayer. The perturbant has a molecular weight between about 150 and about 600 daltons, and contains at least one hydrophilic moiety and at least one hydrophobic moiety. The supramolecular complex comprises the perturbant non-covalently bound or complexed with the biologically active agent. In the present invention, the biologically active agent does not form a microsphere after interacting with the perturbant. A method for preparing an orally administrable biologically active agent comprising steps (a) and (b) above is also provided as are oral delivery compositions. Additionally, mimetics and methods for preparing mimetics are contemplated.

  跨越细胞膜或脂质双层传输生物活性物质的方法。第一种方法包括以下步骤：（a）提供一种生物活性物质，该生物活性物质可以存在于原生构象状态、变性构象状态和中间构象状态，该中间构象状态可逆转至原生状态，且在构象上介于原生态和变性态之间；（b）将生物活性物质暴露于复合扰动剂中，以可逆地将生物活性物质转变为中间状态，并形成可传输的超分子复合物；（c）将膜或双层暴露于超分子复合物中，以跨越膜或双层传输生物活性物质。扰动剂的分子量介于约150至约600道尔顿之间，并含有至少一个亲水性基团和至少一个疏水性基团。超分子复合物包括非共价地结合或复合的扰动剂和生物活性物质。在本发明中，生物活性物质与扰动剂相互作用后不会形成微球。还提供了一种制备口服生物活性物质的方法，包括上述步骤（a）和（b），以及口服给药组合物。此外，还考虑了类似物和制备类似物的方法。
• Glycerin triester plasticizer
  申请人：——

  公开号：US20030116750A1

  公开（公告）日：2003-06-26

  The present invention provides a phthalate-free plasticizer for polymer resins. The phthalate-free plasticizer according to the invention includes a mixture of different triesters of glycerin, at least one of which meets the formula: CH 2 (OOR 1 )CH(OOR 2 )CH 2 (OOR 3 ) wherein at least two of R 1 , R 2 , and R 3 are different alkyl or aryl groups. Phthalate-free plasticizers according to the invention can be made by esterifying glycerin with a mixture of acids in the presence of a catalyst. Preferably, the mixture of acids includes at least two selected from the group consisting of alkyl acids and aryl acids, with each acid in the mixture containing up to about 11 carbon atoms, and more preferably from about 4 to about 9 carbon atoms each. The plasticizer according to the invention can be used to modify the properties of a wide variety of polymers including vinyl polymers, rubbers, polyurethanes, and acrylics, and has superb thermostability and low volatility.

  本发明提供了一种用于聚合物树脂的不含邻苯二甲酸盐的增塑剂。根据本发明，不含邻苯二甲酸盐的增塑剂包括不同甘油三酯的混合物，其中至少有一种符合以下式子： CH 2 (OOR 1 ) CH(OOR 2 ) CH 2 (OOR 3 ) 其中至少两个 R 1 , R 2 和 R 3 是不同的烷基或芳基。根据本发明，不含邻苯二甲酸酯的增塑剂可通过在催化剂存在下将甘油与酸的混合物酯化而制成。酸混合物最好包括至少两种从烷基酸和芳基酸组成的组中选出的酸，混合物中的每种酸最多含有约 11 个碳原子，更优选的是每种酸含有约 4 至约 9 个碳原子。本发明的增塑剂可用于改变包括乙烯基聚合物、橡胶、聚氨酯和丙烯酸树脂在内的多种聚合物的性能，并具有极佳的热稳定性和低挥发性。
• Glycerin Triester Plasticizer
  申请人：Ferro Corporation

  公开号：US20040106819A1

  公开（公告）日：2004-06-03

  The present invention provides a phthalate-free plasticizer for polymer resins. The phthalate-free plasticizer according to the invention includes a mixture of different triesters of glycerin, at least one of which meets the formula: CH 2 (OOR 1 )CH(OOR 2 )CH 2 (OOR 3 ) wherein at least two of R 1 , R 2 , and R 3 are different alkyl or aryl groups. Phthalate-free plasticizers according to the invention can be made by esterifyng glycerin with a mixture of acids in the presence of a catalyst. Preferably, the mixture of acids includes at least two selected from the group consisting of alkyl acids and aryl acids, with each acid in the mixture containing up to about 11 carbon atoms, and more preferably from about 4 to about 9 carbon atoms each. The plasticizer according to the invention can be used to modify the properties of a wide variety of polymers including vinyl polymers, rubbers, polyurethanes, and acrylics, and has superb thermostability and low volatility.

  本发明提供了一种用于聚合物树脂的不含邻苯二甲酸盐的增塑剂。根据本发明，不含邻苯二甲酸盐的增塑剂包括不同甘油三酯的混合物，其中至少有一种符合以下式子： CH 2 (OOR 1 ) CH(OOR 2 ) CH 2 (OOR 3 ) 其中至少两个 R 1 , R 2 和 R 3 是不同的烷基或芳基。根据本发明，不含邻苯二甲酸酯的增塑剂可通过在催化剂存在下将甘油与酸的混合物酯化而制成。酸混合物最好包括至少两种从烷基酸和芳基酸组成的组中选出的酸，混合物中的每种酸最多含有约 11 个碳原子，每种酸最好含有约 4 至约 9 个碳原子。本发明的增塑剂可用于改变包括乙烯基聚合物、橡胶、聚氨酯和丙烯酸树脂在内的多种聚合物的性能，并具有极佳的热稳定性和低挥发性。
• Fieser et al., Journal of the American Chemical Society, 1948, vol. 70, p. 3177
  作者：Fieser et al.

  DOI：——

  日期：——
• Yohe; Adams, Journal of the American Chemical Society, 1928, vol. 50, p. 1506
  作者：Yohe、Adams

  DOI：——

  日期：——