2,3-Dihydroxy-N-benzoyl-serin | 21948-09-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,3-Dihydroxy-N-benzoyl-serin
• 英文别名: 2,3-Dihydroxy-N-benzoylserin；2,3-Dihydroxy-n-benzoylserine；2-[(2,3-dihydroxybenzoyl)amino]-3-hydroxypropanoic acid
• CAS: 21948-09-4
• 化学式: C₁₀H₁₁NO₆
• 分子量: 241.2
• InChiKey: VDTYHTVHFIIEIL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  127
• 氢给体数：
  5
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2,3-二苄氧基苯甲醛 在 palladium on activated charcoal 、 N,N-二甲基甲酰胺 sodium chlorite 、 草酰氯 、 氨基磺酸 、 氢气 、 N,N-二异丙基乙胺 、 锌 作用下， 以 四氢呋喃 、 水 、 丙酮 、 苯 为溶剂， 反应 8.5h， 生成 2,3-Dihydroxy-N-benzoyl-serin
  参考文献：
  名称：

  Synthesis of iron chelators. Enterobactin, enantioenterobactin, and a chiral analog

  摘要：

  DOI：

  10.1021/jo00331a001

文献信息

• [EN] ANTIBACTERIAL SIDEROMYCINS<br/>[FR] SIDÉROMYCINES ANTIBACTÉRIENNES
  申请人：MILLER MARVIN J

  公开号：WO2016027262A1

  公开（公告）日：2016-02-25

  A compound, comprising: an Fe(III)-binding and/or Fe(III)-bound siderophore; one or more optional linker covalently bound to the siderophore; and daptomycin covalently bound to the linker, or, if no linker is present, then to the siderophore; or pharmaceutically acceptable salt or solvate thereof.

  一种化合物，包括：与Fe(III)结合和/或Fe(III)结合的铁载体；一个或多个可选的与铁载体共价结合的连接剂；以及共价结合到连接剂的达托霉素，或者如果没有连接剂存在，则共价结合到铁载体；或其药用可接受的盐或溶剂。
• [EN] CYCLIC PEROXIDES AS PRODRUGS FOR SELECTIVE DELIVERY OF AGENTS<br/>[FR] PEROXYDES CYCLIQUES UTILISÉS EN TANT QUE PROMÉDICAMENTS POUR L'ADMINISTRATION SÉLECTIVE D'AGENTS
  申请人：UNIV CALIFORNIA

  公开号：WO2015123595A1

  公开（公告）日：2015-08-20

  Disclosed herein, inter alia, are prodrug compositions and methods of using the same for treatment and detection of disease. Specifically, disclosed herein is a compound of formula (I) having spiro-fused 1,2,4-trioxolane and piperidine rings, namely, 1,2,4-trioxa- 8-azaspiro[4.5] decane. Also disclosed is a pharmaceutical composition containing the compound and a phannaceutically acceptable carrier.

  本文披露了前药组合物及其用于治疗和检测疾病的方法。具体地，本文披露了一种具有螺合1,2,4-三噁烷和哌啶环的化合物的公式(I)，即1,2,4-三氧杂-8-氮杂螺[4.5]癸烷。还披露了含有该化合物和药用载体的药物组合物。
• [EN] NGAL-BINDING SIDEROPHORES AND USE THEREOF TO TREAT IRON DEFICIENCY AND IRON OVERLOAD<br/>[FR] SIDÉROPHORES SE LIANT À NGAL ET UTILISATION DE CEUX-CI POUR TRAITER UNE CARENCE EN FER ET UNE SURCHARGE EN FER
  申请人：UNIV COLUMBIA

  公开号：WO2010033847A1

  公开（公告）日：2010-03-25

  The invention provides compositions comprising a lipocalin, such as NGAL, and a mammalian siderophore that are useful as iron chelators and iron donors. The invention also provides mammalian siderophore compounds of Formula (I): The invention further provides, methods of treatment and methods of diagnosis.

  本发明提供了包含脂联素（如NGAL）和哺乳动物铁载体的组合物，这些组合物可用作铁螯合剂和铁供体。本发明还提供了公式（I）的哺乳动物铁载体化合物。此外，本发明还提供了治疗方法和诊断方法。
• Siderophore conjugates of photoactive dyes for photodynamic therapy
  申请人：CeramOptec Industries, Inc.

  公开号：US20040186087A1

  公开（公告）日：2004-09-23

  Siderophore-photosensitizer conjugates, their synthesis and use in photodynamic antimicrobial therapy (PACT) is disclosed. The advantage of this method is improvement of photodynamic antimicrobial therapy against, for example, pathogenic micro-organisms such as bacteria and fungi. Naturally occurring and synthetically available siderophore structures are conjugated chemically with photoactive compounds such as Chlorin e 6 to improve their penetration into bacterial cells and to increase antibacterial efficacy of photosensitizers via microbial proteins that recognize and transport iron-loaded siderophores. In this way, photosensitizers can be transported inside bacteria that otherwise could not cross the cell wall and membranes. Photodynamic activation of photosensitizers inside the cells of pathogenic microbes enables a more effective inhibition of cellular functions than application at the outer side of the cells. The siderophore-transporting systems of microbes are known to be specific for bacteria and fungi. Consequently, siderophore conjugates with photosensitizers are not taken up by mammalian cells and photodynamic effects can thus be exerted specifically on pathogenic microbes. Applications of these conjugates include highly efficient treatment of pathogenic gram-negative and -positive bacteria such as Pseudomonas aeruginosa, Escherichia coli, Streptococcus pyogenes, Staphylococcus aureus , treatment of microbial infections that often occur in chronic wounds as well as therapy of other antibiotic resistant microbial infections.

  本文介绍了铁载体-光敏剂共轭物的合成和在光动力抗微生物治疗（PACT）中的应用。该方法的优点是改善了光动力抗微生物治疗，例如对抗细菌和真菌这样的病原微生物。通过化学手段将天然存在和人工合成的铁载体结构与光活性化合物（例如氯林e6）结合，可以提高光敏剂进入细菌细胞的渗透性，并通过识别和运输铁载体的微生物蛋白质增加光敏剂的抗菌效力。通过这种方式，光敏剂可以被运输到细菌内部，否则无法穿过细胞壁和膜。在病原微生物的细胞内激活光敏剂，可以更有效地抑制细胞功能，而不是在细胞外应用。微生物的铁载体运输系统已知对细菌和真菌具有特异性。因此，铁载体共轭物与光敏剂不会被哺乳动物细胞摄取，从而可以针对病原微生物特异性地施加光动力效应。这些共轭物的应用包括高效治疗病原的革兰氏阴性和阳性细菌，例如铜绿假单胞菌，大肠杆菌，链球菌，金黄色葡萄球菌，治疗常见于慢性伤口的微生物感染以及其他抗生素耐药微生物感染的治疗。
• Bacillus subtilis siderophore genes
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0597185A1

  公开（公告）日：1994-05-18

  The present invention relates to an isolated nucleic fragment comprising a Gram-positive bacterial siderophore biosynthetic gene.

  本发明涉及一种包含革兰氏阳性细菌苷元生物合成基因的分离核片段。