2-acetyl-5-methoxyfuran | 65827-50-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-acetyl-5-methoxyfuran
• 英文别名: 1-(5-Methoxyfuran-2-yl)ethanone
• CAS: 65827-50-1
• 化学式: C₇H₈O₃
• 分子量: 140.139
• InChiKey: VJRMEROKMGZTOZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  39.4
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PARASITIC DISEASES
  申请人：BIGGART Agnes

  公开号：US20150175613A1

  公开（公告）日：2015-06-25

  The present invention provides compounds of Formula A: or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a parasite, such as leishmaniasis, human African trypanosomiasis and Chagas disease.

  本发明提供了Formula A的化合物：或其药学上可接受的盐、互变异构体或立体异构体，其中变量如本文所定义。本发明还提供了包含这种化合物的药物组合物，并使用这种化合物治疗、预防、抑制、改善或根除由寄生虫引起的疾病的病理学和/或症状学的方法，如利什曼病、人类非洲锥虫病和光照病。
• CHROMATOGRAPHY METHOD FOR THE PURIFICATION OF FURFURAL DERIVATIVES
  申请人：BASF SE

  公开号：EP3498699A1

  公开（公告）日：2019-06-19

  A liquid chromatography process for the purification of furfural derivative(s), comprising: a. Introducing a feed mixture comprising at least one furfural derivative and other compounds onto a chromatographic bed comprising a silicate-based material as stationary phase, and b. Flushing a liquid comprising an organic acid as mobile phase through the chromatographic bed producing an eluate comprising at least one fraction enriched in at least one furfural derivative and at least one fraction enriched in the other compounds.

  一种提纯糠醛衍生物的液相色谱法，包括 a.将包含至少一种糠醛衍生物和其他化合物的进料混合物引入由硅酸盐材料作为固定相的色谱床，以及 b.将包含有机酸的液体作为流动相冲洗色谱床，产生洗脱液，洗脱液包含至少一种富含至少一种糠醛衍生物的馏分和至少一种富含其他化合物的馏分。
• Compounds and compositions for the treatment of parasitic diseases
  申请人：NOVARTIS AG

  公开号：US10596175B2

  公开（公告）日：2020-03-24

  The present invention provides compounds of Formula A: or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a parasite, such as leishmaniasis, human African trypanosomiasis and Chagas disease.

  本发明提供了式 A 的化合物： 或其药学上可接受的盐、同系物或立体异构体，其中变量如本文所定义。本发明进一步提供了包含此类化合物的药物组合物以及使用此类化合物治疗、预防、抑制、改善或根除寄生虫引起的疾病（如利什曼病、人类非洲锥虫病和南美锥虫病）的病理和/或症状的方法。
• METHOD FOR THE SYNTHESIS OF 5-ALKOXYMETHYL FURFURAL ETHERS AND THEIR USE
  申请人：Furanix Technologies B.V

  公开号：EP2004620A2

  公开（公告）日：2008-12-24
• Verbindungen als Bradykinin-B1-Antagonisten
  申请人：Boehringer Ingelheim International GmbH

  公开号：EP2401256B1

  公开（公告）日：2013-04-17