2,4,6,3,5-pentahydroxycyclohexanone | 13124-19-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,4,6,3,5-pentahydroxycyclohexanone
• 英文别名: myo-Inosose-2；DL-epi-Inosose-2；Inosose；2,3,4,5,6-Pentahydroxycyclohexanone；2,3,4,5,6-pentahydroxycyclohexan-1-one
• CAS: 13124-19-1
• 化学式: C₆H₁₀O₆
• 分子量: 178.142
• InChiKey: VYEGBDHSGHXOGT-UHFFFAOYSA-N

物化性质

• 熔点：
  198 °C (decomp)
• 沸点：
  368.6±42.0 °C(Predicted)
• 密度：
  2.026±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -3.3
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  118
• 氢给体数：
  5
• 氢受体数：
  6

文献信息

• Method for Producing Scyllo-Inositol
  申请人：Asahi Kasei Chemicals Corporation

  公开号：US20140370549A1

  公开（公告）日：2014-12-18

  The disclosure provides a method of producing a scyllo-inositol or a new scyllo-inositol derivative in a one-step process, from ubiquitous and inexpensive raw materials. Also provided is a scyllo-inositol derivative bonded to saccharides such as glucose and similar.

  该披露提供了一种通过一步工艺从普遍和廉价的原材料中生产scyllo-肌醇或新的scyllo-肌醇衍生物的方法。还提供了一种与葡萄糖等糖类结合的scyllo-肌醇衍生物。
• METHOD FOR PRODUCING SCYLLO-INOSITOL
  申请人：YAMAGUCHI MASANORI

  公开号：US20100261238A1

  公开（公告）日：2010-10-14

  It is intended to provide a novel NAD + -independent myo-inositol 2-dehydrogenase which converts myo-inositol into scyllo-inosose in the absence of NAD + ; a novel enzyme scyllo-inositol dehydrogenase which stereospecifically reduces scyllo-inosose into scyllo-inositol in the presence of NADH or NADPH; and a novel microorganism which belongs to the genus Acetobacter or Burkholderia and can convert myo-inositol into scyllo-inositol. By using these enzymes or the microorganism, scyllo-inositol is produced. Furthermore, scyllo-inositol is purified by adding boric acid and a metal salt to a liquid mixture containing scyllo-inositol and a neutral saccharide other than scyllo-inositol to fonts a scyllo-inositol/boric acid complex, separating the complex from the liquid mixture, dissolving the thus separated complex in an acid to give an acidic solution or an acidic suspension and then purifying scyllo-inositol from the acidic solution or the acidic suspension.

  本发明旨在提供一种新型的NAD +无关的肌醇2-脱氢酶，该酶在缺乏NAD +的情况下将肌醇转化为赛洛肌醇；一种新型的赛洛肌醇脱氢酶，该酶在存在NADH或NADPH的情况下立体特异性地将赛洛肌醇还原为赛洛肌醇；以及一种新的微生物，属于Acetobacter或Burkholderia属，可以将肌醇转化为赛洛肌醇。通过使用这些酶或微生物，可以生产赛洛肌醇。此外，通过向含有赛洛肌醇和除赛洛肌醇以外的中性糖的液体混合物中添加硼酸和金属盐来纯化赛洛肌醇，形成赛洛肌醇/硼酸复合物，将复合物与液体混合物分离，将分离出的复合物溶解在酸中以得到酸性溶液或酸性悬浮液，然后从酸性溶液或酸性悬浮液中纯化赛洛肌醇。
• Method for producing scyllo-inositol
  申请人：HOKKO CHEMICAL INDUSTRY CO., LTD.

  公开号：EP2058390A1

  公开（公告）日：2009-05-13

  It is intended to provide a novel NAD+-independent myo-inositol 2-dehydrogenase which converts myo-inositol into scyllo-inosose in the absence of NAD+; a novel enzyme scyllo-inositol dehydrogenase which stereospecifically reduces scyllo-inosose into scyllo-inositol in the presence of NADH or NADPH; and a novel microorganism which belongs to the genus Acetobacter or Burkholderia and can convert myo-inositol into scyllo-inositol. By using these enzymes or the microorganism, scyllo-inositol is produced. Furthermore, scyllo-inositol is purified by adding boric acid and a metal salt to a liquid mixture containing scyllo-inositol and a neutral saccharide other than scyllo-inositol to form a scyllo-inositol/boric acid complex, separating the complex from the liquid mixture, dissolving the thus separated complex in an acid to give an acidic solution or an acidic suspension and then purifying scyllo-inositol from the acidic solution or the acidic suspension.

  旨在提供一种新型的不依赖于 NAD+ 的肌醇 2-脱氢酶，该酶可在缺乏 NAD+ 的情况下将肌醇转化为酰基肌醇糖；一种新型的酰基肌醇脱氢酶，它能在有 NADH 或 NADPH 的情况下，立体特异性地将酰基肌醇还原成酰基肌醇；以及一种新型微生物，它属于醋酸菌属或伯克霍尔德菌属，能将肌醇转化成酰基肌醇。通过使用这些酶或微生物，可以生产出木质素肌醇。此外，提纯木质素肌醇的方法是：向含有木质素肌醇和除木质素肌醇以外的中性糖的液体混合物中加入硼酸和金属盐，形成木质素肌醇/硼酸复合物，将复合物从液体混合物中分离出来，将分离出来的复合物溶解在酸中，得到酸性溶液或酸性悬浮液，然后从酸性溶液或酸性悬浮液中提纯木质素肌醇。
• Methods of preventing, treating and diagnosing disorders of protein aggregation
  申请人：McLaurin, Joanne

  公开号：EP2153829A1

  公开（公告）日：2010-02-17

  Disclosed are methods of preventing, treating, or diagnosing in a subject a disorder in protein folding or aggregation., or amyloid formation., deposition, accumulation, or persistence consisting of administering to said subject a pharmaceutically effective amount of inositol stereoisomers, enantiomers or derivatives thereof.

  所公开的是预防、治疗或诊断受试者蛋白质折叠或聚集紊乱，或淀粉样蛋白形成、沉积、积累或持久性的方法，包括向所述受试者施用药学上有效量的肌醇立体异构体、对映体或其衍生物。
• SCYLLO-INOSITOL-PRODUCING CELL AND SCYLLO-INOSITOL PRODUCTION METHOD USING SAID CELLS
  申请人：National University Corporation Kobe University

  公开号：EP2357222A1

  公开（公告）日：2011-08-17

  An object of the present invention is to provide a cell capable of efficiently producing scyllo-inositol from myo-inositol and a simple method of manufacturing scyllo-inositol using the cell. The above-mentioned object is achieved by a Bacillus subtilis cell, in which a function of a protein having a scyllo-inositol dehydrogenase activity is lost, and the manufacture of scyllo-inositol using the cell, based on a novel finding that the protein having a scyllo-inositol dehydrogenase activity and a protein having a 2-keto-myo-inositol ketoreductase function are present in Bacillus subtilis.

  本发明的一个目的是提供一种能够从肌醇中有效生产酰基肌醇的细胞，以及使用该细胞生产酰基肌醇的简单方法。上述目的是通过一种枯草芽孢杆菌细胞来实现的，在该细胞中，具有酰基肌醇脱氢酶活性的蛋白质的功能丧失，并利用该细胞制造酰基肌醇，其依据是一项新发现，即具有酰基肌醇脱氢酶活性的蛋白质和具有 2-酮-肌醇酮还原酶功能的蛋白质存在于枯草芽孢杆菌中。