2-[[4-Ethoxy-2-(nitrosomethyl)oxolan-3-yl]methyl]-4-ethyl-6-(1,2,4-oxadiazetidin-3-yl)oxane-3,5-diol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-[[4-Ethoxy-2-(nitrosomethyl)oxolan-3-yl]methyl]-4-ethyl-6-(1,2,4-oxadiazetidin-3-yl)oxane-3,5-diol
• 英文别名: 2-[[4-ethoxy-2-(nitrosomethyl)oxolan-3-yl]methyl]-4-ethyl-6-(1,2,4-oxadiazetidin-3-yl)oxane-3,5-diol
• 化学式: C₁₆H₂₉N₃O₇
• 分子量: 375.42
• InChiKey: VXXLTLGXBMRVIT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  26
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  131
• 氢给体数：
  4
• 氢受体数：
  10

文献信息

• Eyedrop comprising agar
  申请人：TORAY INDUSTRIES INC.

  公开号：EP2213308A1

  公开（公告）日：2010-08-04

  It is intended to prepare a composition which contains polysaccharide at a high concentration and yet remains in the state of a liquid having low viscosity to thereby provide drugs, eyedrops, foods, cosmetics, toiletry products having a novel texture or function. The composition in the state of a liquid having low viscosity is obtained by heating polysaccharide at a high concentration in a water-containing liquid and then cooling under applying a shear force, which enables the provision of the above-described drugs. The composition is usable as an aqueous drug vehicle which is free from gelling due to temperature changes during storage and easily applied without pouring and/or streaming down. Eyedrops containing agar have an effect of enhancing ocular drug penetration. Eyedrops containing particulate agar maintain a low viscosity and, achieve easy instillation and impart a favorable feel in instillation.

  其目的是制备一种含有高浓度多糖但仍保持低粘度液体状态的组合物，从而提供具有新颖质地或功能的药物、眼药水、食品、化妆品、盥洗用品。通过在含水液体中加热高浓度多糖，然后在施加剪切力的情况下冷却，可获得低粘度液体状态的组合物，从而提供上述药物。该组合物可用作水性药物载体，在储存过程中不会因温度变化而凝胶化，并且易于使用，不会倾倒和/或流下。含有琼脂的眼药水具有增强眼部药物渗透的效果。含有微粒琼脂的眼药水能保持较低的粘度，易于滴注，并在滴注时产生良好的感觉。