Trestatin B | 71869-92-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Trestatin B
• 英文别名: 2-[5-[5-[5-[3,4-dihydroxy-6-methyl-5-[[4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino]oxan-2-yl]oxy-3,4-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,4-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,4-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol
• CAS: 71869-92-6
• 化学式: C₃₇H₆₃NO₂₈
• 分子量: 969.9
• InChiKey: WEDWQCPYKKZMDF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -12.3
• 重原子数：
  66
• 可旋转键数：
  15
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  480
• 氢给体数：
  20
• 氢受体数：
  29

文献信息

• Treatment of rumen acidosis with alpha-amylase inhibitors
  申请人：Pfizer Limited

  公开号：EP1745790A2

  公开（公告）日：2007-01-24

  Inhibitors of rumen bacterial alpha-amylase and/or alpha-glucosidase are useful in the preparation of medicaments for the curative, palliative and prophylactic treatment of rumen acidosis and secondary conditions of rumen acidosis.

  瘤胃细菌α-淀粉酶和/或α-葡萄糖苷酶抑制剂可用于制备治疗、缓解和预防瘤胃酸中毒和继发性瘤胃酸中毒的药物。
• AMINOSUGAR COMPOUND AND PROCESS FOR PRODUCTION THEREOF
  申请人：Sasamura Satoshi

  公开号：US20110105420A1

  公开（公告）日：2011-05-05

  [Object] Disclosed is a compound useful as an active ingredient for a pharmaceutical composition having an α-amylase inhibitory activity, particularly a pharmaceutical composition for the treatment of diabetes. [Solution] An investigation has been made on a compound having an α-amylase inhibitory activity among the compounds produced by Streptomyces sp. strain 6982, which is a actinomycetes belonging to the genus Streptomyces , and it was confirmed that an aminosugar compound has an α-amylase inhibitory activity, thus completing the invention. The aminosugar compound of the present invention has an α-amylase-inhibitory activity, and therefore can be used as a prophylactic or therapeutic agent for diabetes, obesity, NASH (non-alcoholic steatohepatitis), particularly as an ameliorating agent for postprandial blood glucose elevation.
• US7271158B2
  申请人：——

  公开号：US7271158B2

  公开（公告）日：2007-09-18