4-(2-formyl-5-hydroxymethylpyrrol-1-yl)butyric acid | 142629-55-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-(2-formyl-5-hydroxymethylpyrrol-1-yl)butyric acid
• 英文别名: 4-[formyl-5-(hydroxymethyl)-1H-pyrrol-1-yl]butanoic acid；2-Formyl-5-(hydroxymethyl)-1h-pyrrole-1-butanoic acid；4-[2-formyl-5-(hydroxymethyl)pyrrol-1-yl]butanoic acid
• CAS: 142629-55-8
• 化学式: C₁₀H₁₃NO₄
• 分子量: 211.218
• InChiKey: WNNGLHOQCHCQFK-UHFFFAOYSA-N

物化性质

• 沸点：
  479.2±45.0 °C(Predicted)
• 密度：
  1.27±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  79.5
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-氨基丁酸 在 maltose 作用下， 以 aq. phosphate buffer 为溶剂， 生成 4-(2-formyl-5-hydroxymethylpyrrol-1-yl)butyric acid
  参考文献：
  名称：

  10.1021/acs.jafc.4c01000

  摘要：

  DOI：

  10.1021/acs.jafc.4c01000

文献信息

• METHOD OF INDUCING APOPTOSIS AND COMPOSITIONS THEREFOR
  申请人：Sundory Co., Ltd.

  公开号：EP1454626A1

  公开（公告）日：2004-09-08

  A novel composition and health food having a good pharmacological activity and which can be readily absorbed through an alimentary canal are provided. The composition induced apoptosis of cells and includes an agaricus extract. The composition may further comprise a pharmaceutically acceptable carrier. Typically, the cells are cancer cells. The composition may further include a differentiation induction agent. Preferably, the differentiation induction agent is a vitamin A derivative. The vitamin A derivative may be tretinoin. The agaricus extract may include a main fraction eluted chromatographically of a molecular weight of 100 to 2000, which is obtained by the steps of extraction with hot water from a fruiting body of agaricus, dialyzing the extract and performing a chromatography process on the dialyzate.

  本研究提供了一种具有良好药理活性且易于通过消化道吸收的新型组合物和保健食品。该组合物可诱导细胞凋亡，其中包括一种姬松茸提取物。该组合物还可进一步包含一种药学上可接受的载体。通常，细胞是癌细胞。该组合物可进一步包括一种分化诱导剂。分化诱导剂最好是维生素 A 衍生物。维生素 A 衍生物可以是曲安奈德。姬松茸提取物可包括经层析洗脱的分子量为100至2000的主馏分，该馏分是通过以下步骤获得的：用热水从姬松茸子实体中提取，透析提取物，并对透析液进行层析处理。
• Method of inducing apoptosis and compositions therefor
  申请人：Mori Takeshi

  公开号：US20050163801A1

  公开（公告）日：2005-07-28

  A novel composition and health food having a good pharmacological activity and which can be readily absorbed through an alimentary canal are provided. The composition induced apoptosis of cells and includes an agaricus extract. The composition may further comprise a pharmaceutically acceptable carrier. Typically, the cells are cancer cells. The composition may further include a differentiation inductionagent. Preferably, the differentiation induction agent is a vitamin A derivative. The vitamin A derivative may be tretinoin. The agaricus extract may include a main fraction eluted chromatographically of a molecular weight of 100 to 2000, which is obtained by the steps of extraction with hot water from a fruiting body of agaricus, dialyzing the extract and performing a,chromatography process on the dialyzate.

  本研究提供了一种具有良好药理活性且易于通过消化道吸收的新型组合物和保健食品。该组合物可诱导细胞凋亡，其中包括一种姬松茸提取物。该组合物还可进一步包含一种药学上可接受的载体。通常，细胞是癌细胞。该组合物可进一步包括一种分化诱导剂。分化诱导剂最好是维生素 A 衍生物。维生素 A 衍生物可以是曲安奈德。姬松茸提取物可包括经层析洗脱的分子量为100至2000的主馏分，该馏分是通过以下步骤获得的：用热水从姬松茸子实体中提取，透析提取物，并对透析液进行层析处理。
• Ninomiya, Masaki; Matsuzaki, Toshiake; Shigematsu, Hitoshi, Bioscience, Biotechnology and Biochemistry, 1992, vol. 56, # 5, p. 806 - 807
  作者：Ninomiya, Masaki、Matsuzaki, Toshiake、Shigematsu, Hitoshi

  DOI：——

  日期：——
• JPH04193862A
  申请人：——

  公开号：JPH04193862A

  公开（公告）日：1992-07-13
• PYRROLE COMPOUND
  申请人：MYCOLOGY TECHNO.CORP.

  公开号：US20200385347A1

  公开（公告）日：2020-12-10

  The present invention provides a pyrrole compound represented by the following formula (1):