2,5-Dimethyl-4-(methylamino)heptan-3-one

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,5-Dimethyl-4-(methylamino)heptan-3-one
• 英文别名: 2,5-dimethyl-4-(methylamino)heptan-3-one
• 化学式: C₁₀H₂₁NO
• 分子量: 171.28
• InChiKey: XFHFBWZJKGUYJX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• TRIPEPTIDE COMPOUND, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF
  申请人：NORTHWEST UNIVERSITY

  公开号：US20170267718A1

  公开（公告）日：2017-09-21

  Provided are a tripeptide compound, a preparation method therefor, and an application thereof. The structure of the related compound is represented by formula (I). The provided compound has angiotensin converting enzyme inhibiting bioactivity, and the compound and a pharmaceutical composition thereof play a role in preventing and treating hypertension and other cardiocerebral vascular system diseases.

  提供了一种三肽化合物，其制备方法和应用。相关化合物的结构由式（I）表示。提供的化合物具有抑制血管紧张素转换酶的生物活性，该化合物及其药物组成对预防和治疗高血压和其他心脑血管系统疾病起着作用。
• Isoform Selective HDAC Inhibitors
  申请人：Kozikowski Alan P.

  公开号：US20100196502A1

  公开（公告）日：2010-08-05

  One aspect of the invention relates to isoform-selective HDAC inhibitors. Also provided are methods of sensitizing a cancer cell to the cytotoxic effects of radiotherapy. The invention also provides methods for treating cancer, methods for treating neurological diseases and methods for treating malaria. Additionally, the invention provides pharmaceutical compositions comprising an HDAC inhibitor of the invention; and kits comprising a an HDAC inhibitor of the invention.

  本发明的一个方面涉及选择性同工酶HDAC抑制剂。还提供了一种使癌细胞对放疗的细胞毒性效应敏感的方法。本发明还提供了治疗癌症、神经系统疾病和疟疾的方法。此外，本发明还提供包含本发明的HDAC抑制剂的制药组合物；以及包含本发明的HDAC抑制剂的试剂盒。
• Compounds useful in the treatment and/or care of the skin, hair, nails, and/or mucous membranes
  申请人：LUBRIZOL ADVANCED MATERIALS, INC.

  公开号：US10799442B2

  公开（公告）日：2020-10-13

  Compounds of general formula (I): R1-Wm-Xn-AA1-AA2-AA3-AA4-AA5-AA6-Yp-Zq-R2 (I) their stereoisomers, mixtures thereof and/or their cosmetically or pharmaceutically acceptable salts, cosmetic and/or pharmaceutical compositions which contain them and their use in medicine, and in processes of treatment and/or care of the skin, hair and/or mucous membranes, in particular in the aging and photoaging of the skin.

  通式 (I) 的化合物：R1-Wm-Xn-AA1-AA2-AA3-AA4-AA5-AA6-Yp-Zq-R2（I）的立体异构体、它们的混合物和/或它们的化妆品或药剂上可接受的盐、含有它们的化妆品和/或药剂组合物，以及它们在医学、皮肤、头发和/或粘膜的治疗和/或护理过程中的用途，尤其是在皮肤老化和光老化方面的用途。
• Tripeptide compound, preparation method therefor, and application thereof
  申请人：NORTHWEST UNIVERSITY

  公开号：US11358985B2

  公开（公告）日：2022-06-14

  Provided are a tripeptide compound, a preparation method therefor, and an application thereof. The structure of the related compound is represented by formula (I). The provided compound has angiotensin converting enzyme inhibiting bioactivity, and the compound and a pharmaceutical composition thereof play a role in preventing and treating hypertension and other cardiocerebral vascular system diseases.

  本文提供了一种三肽化合物、其制备方法及其应用。相关化合物的结构由式（I）表示。所提供的化合物具有抑制血管紧张素转换酶的生物活性，该化合物及其药物组合物在预防和治疗高血压及其他心脑血管系统疾病中发挥作用。