5-Amino-2-(hydroxymethyl)-6-methyloxane-3,4-diol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-Amino-2-(hydroxymethyl)-6-methyloxane-3,4-diol
• 化学式: C₇H₁₅NO₄
• 分子量: 177.2
• InChiKey: XJSPDRFMLGJORM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.9
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  95.9
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• GLYCOPEPTIDE COMPOUNDS, METHODS FOR PRODUCING THE SAME, AND USES THEREOF
  申请人：Academia Sinica

  公开号：US20200291071A1

  公开（公告）日：2020-09-17

  Disclosed herein are novel compounds and uses thereof. The present compounds are useful in suppressing the growth of various bacteria, including gram-positive and gram-negative bacteria. Accordingly, these compounds may be used to manufacture a medicament or pharmaceutic composition for treating disease and/or disorders associated with bacterial infection, especially antibiotic-resistant bacterial infection. Al so disclosed herein are methods for treating infectious diseases by use of the present compounds, medicament or pharmaceutical composition.

  本文披露了新颖的化合物及其用途。这些化合物可用于抑制各种细菌的生长，包括革兰氏阳性和阴性细菌。因此，这些化合物可用于制造治疗与细菌感染有关的疾病和/或疾病的药物或药学组合物，特别是抗生素耐药性细菌感染。本文还披露了利用这些化合物、药物或药学组合物治疗传染病的方法。
• SYNTHESIS METHOD OF GLYCO-DRUG RADIOTRACER PRECURSOR
  申请人：LU Kuei-Lin

  公开号：US20140066609A1

  公开（公告）日：2014-03-06

  A novel synthesis method of Glyco-drug radiotracer precursor is revealed. After completing synthesis of Z-Gly-ah (main structure), galactosamine GalNAc(OAc) 4 is added to have coupling reaction. Then a product is separated directly from dichloromethane. Thus loss of galactosamine during extraction with liquid chromatography is reduced. Moreover, instead of trifluoroacetyl group, carbobenzoxy (abbreviated as Cbz or Z) is used as a protecting group to ensure uniformity of the phase. The cost and synthesis time are also dramatically reduced.

  揭示了一种新的糖基药物放射性示踪剂前体的合成方法。完成主要结构Z-Gly-ah的合成后，加入甘露胺GalNAc(OAc)4进行偶联反应。然后直接从二氯甲烷中分离产物。因此，液相色谱提取过程中甘露胺的损失得到了减少。此外，保护基使用碳苯氧基（简称Cbz或Z）以确保相位的一致性，而不是三氟乙酰基。成本和合成时间也大大降低。
• SYNTHETIC LIPOAMINO ACID GLUCOSAMINE DERIVATIVES FOR IMPROVEMENT OF PLANT GROWTH AND YIELD
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：US20160021879A1

  公开（公告）日：2016-01-28

  The invention provides compounds, formulations and methods for improving plant emergence, growth and yield. More specifically, the present invention relates to compositions comprising the synthetic lipoamino acid glucosamine compounds of Formula I. These compounds may be applied to plant propagating materials, including seeds and other regenerable plant parts, including cuttings, bulbs, rhizomes and tubers. They may also be applied to foliage, or soil either prior to or following planting of plant propagating materials. Such applications may be made alone or in combination with fungicides, insecticides, nematicides and other agricultural agents used to improve plant growth and crop yield. The compounds of Formula I can improve the agronomic performance of a variety of crops including barley, canola, corn, potato, soybean and wheat.

  本发明提供了用于改善植物出苗、生长和产量的化合物、配方和方法。更具体地说，本发明涉及包含化学合成的脂肽氨基糖化合物（公式I）的组合物。这些化合物可以应用于植物繁殖材料，包括种子和其他可再生植物部分，包括插条、鳞茎、根茎和块茎。它们也可以应用于叶片或土壤，无论是在种植植物繁殖材料之前还是之后。这种应用可以单独进行，也可以与杀菌剂、杀虫剂、线虫灭生剂和其他用于改善植物生长和作物产量的农业剂一起使用。公式I的化合物可以改善各种作物的农艺性能，包括大麦、油菜、玉米、马铃薯、大豆和小麦。
• ANALYTICAL METHOD FOR CHONDROITIN SULFATE
  申请人：JCR Pharmaceuticals Co., Ltd.

  公开号：EP3842800A1

  公开（公告）日：2021-06-30

  Disclosed is a method for decomposing chondroitin sulfate contained in a sample into disaccharide. In particular disclosed is a method for decomposing chondroitin sulfate contained in a sample into disaccharide by heating the chondroitin sulfate in HCl-methanol containing 2,2-dimethoxypropane at a temperature of 60°C to 90°C for 50 minutes to 180 minutes, optionally in the method, the sample is selected from body fluid, a cell, a tissue, an organ, a cell culture solution, a tissue culture solution, a food, and a feed, or a derived therefrom.

  公开了一种将样品中所含硫酸软骨素分解成二糖的方法。特别是公开了一种将样品中所含的硫酸软骨素分解成二糖的方法，该方法是将硫酸软骨素在含有 2,2-二甲氧基丙烷的盐酸-甲醇中，在 60°C 至 90°C 的温度下加热 50 分钟至 180 分钟，在该方法中，样品可选自体液、细胞、组织、器官、细胞培养液、组织培养液、食品和饲料或其衍生品。
• Synthetic oligomers of Neisseria meningitis serogroup X and process of preparing them
  申请人：MSD WELLCOME TRUST HILLEMAN LABORATORIES PVT. LTD.

  公开号：US10183962B2

  公开（公告）日：2019-01-22

  The present invention relates to synthesis of novel higher oligomers and process of preparing the same. In particular the present invention relates to the chemical synthesis of oligomers of Neisseria meningitidis serogroup X (‘hereinafter Men-X), more particularly tetramer. The present invention provides Men-X capsular oligomers obtained from synthetic pathway using purified saccharides of specific chain length and provides said novel oligomers as candidates for the development of conjugate vaccine against bacterial meningitis caused due to Men-X infections.

  本发明涉及新型高级低聚物的合成及其制备工艺。特别是本发明涉及脑膜炎奈瑟菌血清群 X（以下简称 Men-X）的低聚物，尤其是四聚体的化学合成。本发明提供了利用特定链长的纯化糖通过合成途径获得的 Men-X 荚膜低聚物，并提供了上述新型低聚物作为候选物，用于开发预防由 Men-X 感染引起的细菌性脑膜炎的结合疫苗。