[3,4,5-Triacetyloxy-6-[4-[2-(diethylamino)ethylcarbamoyl]-2-methoxyphenoxy]oxan-2-yl]methyl acetate

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [3,4,5-Triacetyloxy-6-[4-[2-(diethylamino)ethylcarbamoyl]-2-methoxyphenoxy]oxan-2-yl]methyl acetate
• 化学式: C₂₈H₄₀N₂O₁₂
• 分子量: 596.6
• InChiKey: YAQKKPAGOYYBGW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  42
• 可旋转键数：
  18
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  165
• 氢给体数：
  1
• 氢受体数：
  13

文献信息

• Methods and compositions for modulating serum cortisol levels
  申请人：Lecanu Laurent

  公开号：US20060194815A1

  公开（公告）日：2006-08-31

  The present invention relates to cortisol-modulating compounds, including but not limited to benzamide and benzoic acid derivatives such as procaine and procaine derivatives, utilized in compositions and methods for treating cortisol-mediated disorders, including but not limited to age-related depression, hypertension, Alzheimer's disease, and acquired immunodeficiency syndrome.

  本发明涉及皮质醇调节化合物，包括但不限于苯甲酰胺和苯甲酸衍生物，如普鲁卡因和普鲁卡因衍生物，用于治疗皮质醇介导的疾病的组合物和方法，包括但不限于年龄相关性抑郁症，高血压，阿尔茨海默病和获得性免疫缺陷综合症。
• Benzamide compounds
  申请人：Papadopoulos Vassilios

  公开号：US20060194814A1

  公开（公告）日：2006-08-31

  The invention provides a therapeutic method for preventing or treating a pathological condition or symptom in a mammal, such as a human, wherein the infectivity of a pathogen such as a retrovirus toward mammalian cells is implicated and inhibition of its infectivity is desired comprising administering to a mammal in need of such therapy, an effective amount of an N-benzamide derivative of a piperazinyl amide of an amino acid thereof that inhibits pathogenic infectivity, including pharmaceutically acceptable salts thereof. The invention also provides a therapeutic method for preventing or treating a neuropathological condition or symptom in a mammal, such as human, comprising administering to a mammal in need of such therapy, an effective amount of an N-benzamide derivative of a piperazinyl amide of an amino acid thereof, including pharmaceutically acceptable salts thereof.

  本发明提供了一种治疗方法，用于预防或治疗哺乳动物（如人类）中的病理状况或症状，其中涉及病原体（如逆转录病毒）对哺乳动物细胞的感染性，并且希望抑制其感染性，包括向需要该疗法的哺乳动物施用有效量的N-苯甲酰基衍生物的哌嗪酰胺及其氨基酸，其抑制了病原体的感染性，包括其药物可接受的盐。本发明还提供了一种治疗方法，用于预防或治疗哺乳动物（如人类）中的神经病理状况或症状，包括向需要该疗法的哺乳动物施用有效量的N-苯甲酰基衍生物的哌嗪酰胺及其氨基酸，包括其药物可接受的盐。
• [EN] BENZAMIDE COMPOUNDS<br/>[FR] COMPOSES BENZAMIDE
  申请人：SAMARITAN PHARMACEUTICALS

  公开号：WO2005112922A2

  公开（公告）日：2005-12-01

  The invention provides a therapeutic method for preventing or treating a pathological condition or symptom in a mammal, such as a human, wherein the infectivity of a pathogen such as a retrovirus toward mammalian cells is implicated and inhibition of its infectivity is desired comprising administering to a mammal in need of such therapy, an effective amount of an N-benzamide derivative of a piperazinyl amide of an amino acid thereof that inhibits pathogenic infectivity, including pharmaceutically acceptable salts thereof. The invention also provides a therapeutic method for preventing or treating a neuropathological condition or symptom in a mammal, such as human, comprising administering to a mammal in need of such therapy, an effective amount of an N-benzamide derivative of a piperazinyl amide of an amino acid thereof, including pharmaceutically acceptable salts thereof.