5,8-Dihydroxy-4a,8a-dihydronaphthalene-1,4-dione | 887574-80-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5,8-Dihydroxy-4a,8a-dihydronaphthalene-1,4-dione
• CAS: 887574-80-3
• 化学式: C₁₀H₈O₄
• 分子量: 192.17
• InChiKey: YBSPYLIZIRGBHN-UHFFFAOYSA-N

物化性质

• 密度：
  1.584

计算性质

• 辛醇/水分配系数(LogP)：
  0.82
• 重原子数：
  14.0
• 可旋转键数：
  0.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  74.6
• 氢给体数：
  2.0
• 氢受体数：
  4.0

文献信息

• PGC-1 -PROTEIN-FUNCTION REGULATOR, MITOCHONDRIA-FUNCTION REGULATOR, ANTI-OBESITY AGENT, AND SCREENING METHOD THEREFOR
  申请人：Nakajima, Toshihiro

  公开号：EP2954905A1

  公开（公告）日：2015-12-16

  [Problem] To provide a mitochondria-function regulator effective for treatment or prevention of obesity, and a screening method therefore. [Solution] The mitochondria-function regulator of the present invention contains, as an active ingredient, a PGC-1β - protein function regulator synoviolin. The screening method of the present invention includes a step for causing a test substance to act on an adipose tissue cell or an individual animal, and measuring or detecting one or more of the following in the adipose tissue cell: (1) expression level of synoviolin; (2) a bond between synoviolin and PGC-1β protein; and (3) the ubiquitination of the PGC-1β protein by synoviolin.

  问题 提供一种有效治疗或预防肥胖症的线粒体功能调节剂及其筛选方法。 [解决方案］ 本发明的线粒体功能调节剂含有一种 PGC-1β - 蛋白质功能调节剂 synoviolin 作为活性成分。本发明的筛选方法包括使测试物质作用于脂肪组织细胞或动物个体，并在脂肪组织细胞中测量或检测以下一项或多项内容的步骤：(1) 滑膜素的表达水平；(2) 滑膜素与 PGC-1β 蛋白之间的结合；(3) 滑膜素对 PGC-1β 蛋白的泛素化。
• Process for manufacturing a densified polymer powder, and process of melt processing a densified polymer powder
  申请人：SABIC GLOBAL TECHNOLOGIES B.V.

  公开号：US10596727B2

  公开（公告）日：2020-03-24

  Process for manufacturing a densified polymer powder comprising compressing a polymer feed that has a bulk density of less than or equal to 240 kg/m in a roll compactor comprising at least two compaction rolls to obtain a densified polymer material, wherein a gap between the two rolls is 0.5 to 10 mm, wherein the compaction rolls operate at a speed of 3 to 30 rpm, wherein an applied pressure of the roll compactor is 0.5 to 5 MPa, and milling the densified polymer material to obtain a densified polymer powder, wherein a bulk density of the densified polymer powder is greater than or equal to 250 kg/m3.

  制造致密聚合物粉末的工艺，包括在由至少两个压实辊组成的辊式压实机中压缩体积密度小于或等于 240 kg/m 的聚合物进料以获得致密聚合物材料，其中两个压实辊之间的间隙为 0.5至10毫米，其中压实辊的运行速度为3至30转/分钟，其中辊式压实机的施加压力为0.5至5兆帕，然后碾磨致密聚合物材料以获得致密聚合物粉末，其中致密聚合物粉末的体积密度大于或等于250千克/立方米。
• SCREENING METHOD FOR PGC-1BETA-PROTEIN-FUNCTION REGULATOR
  申请人：Nakajima, Toshihiro

  公开号：EP2954905B1

  公开（公告）日：2018-05-02
• PGC-1beta-Protein-Function Regulator, Mitochondria-Function Regulator, Anti-Obesity Agent, And Screening Method Therefor
  申请人：NAKAJIMA Toshihiro

  公开号：US20150330981A1

  公开（公告）日：2015-11-19

  [Problem] To provide a mitochondria-function regulator effective for treatment or prevention of obesity, and a screening method therefore. [Solution] The mitochondria-function regulator of the present invention contains, as an active ingredient, a PGC-1β-protein function regulator synoviolin. The screening method of the present invention includes a step for causing a test substance to act on an adipose tissue cell or an individual animal, and measuring or detecting one or more of the following in the adipose tissue cell: (1) expression level of synoviolin; (2) a bond between synoviolin and PGC-1β protein; and (3) the ubiquitination of the PGC-1β protein by synoviolin.
• PROCESS FOR MANUFACTURING A DENSIFIED POLYMER POWDER, AND PROCESS OF MELT POLYMERIZING A DENSIFIED POLYMER POWDER
  申请人：SABIC GLOBAL TECHNOLOGIES B.V.

  公开号：US20170232640A1

  公开（公告）日：2017-08-17

  Process for manufacturing a densified polymer powder comprising compressing a polymer feed that has a bulk density of less than or equal to 240 kg/m in a roll compactor comprising at least two compaction rolls to obtain a densified polymer material, wherein a gap between the two rolls is 0.5 to 10 mm, wherein the compaction rolls operate at a speed of 3 to 30 rpm, wherein an applied pressure of the roll compactor is 0.5 to 5 MPa, and milling the densified polymer material to obtain a densified polymer powder, wherein a bulk density of the densified polymer powder is greater than or equal to 250 kg/m3.