13,15-Triacontanedione | 81116-08-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 13,15-Triacontanedione
• 英文别名: triacontane-13,15-dione
• CAS: 81116-08-7
• 化学式: C₃₀H₅₈O₂
• 分子量: 450.8
• InChiKey: YQBCWBGXIHUJSX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  12.8
• 重原子数：
  32
• 可旋转键数：
  27
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• LONG-CIRCULATING LIPOSOME MODIFIED WITH C(RGD-ACP-K)
  申请人：Beijing Greatsun Bio-pharm. Tech. Co., Ltd

  公开号：EP3632413A1

  公开（公告）日：2020-04-08

  The present invention relates to a long-circulating liposome modified with c(RGD-ACP-K). The present invention pertains to the field of pharmaceutical preparations, in particular to the field of targeted pharmaceutical preparations. More specifically, the present invention relates to a long-circulating liposome, the surface of the liposome being modified with c(RGD-ACP-K), and the liposome comprising doxorubicin or a pharmaceutically acceptable salt thereof such as doxorubicin hydrochloride as an anti-cancer active agent. The long-circulating liposome can targetedly deliver the anti-cancer active agent into tumor neovascular endothelial cells and tumor cells and can prolong the circulation time of the liposome in vivo, thereby enhancing the therapeutic effect of anti-tumor medicaments.

  本发明涉及一种用 c(RGD-ACP-K)修饰的长循环脂质体。本发明涉及药物制剂领域，特别是靶向药物制剂领域。更具体地说，本发明涉及一种长循环脂质体，脂质体的表面用c(RGD-ACP-K)修饰，脂质体包含作为抗癌活性剂的多柔比星或其药学上可接受的盐，如盐酸多柔比星。长循环脂质体可将抗癌活性剂靶向递送到肿瘤新生血管内皮细胞和肿瘤细胞中，延长脂质体在体内的循环时间，从而提高抗肿瘤药物的治疗效果。
• Long-circulating liposome modified with c(RGD-ACP-K)
  申请人：BEIJING GREATSUN BIO-PHARM. TECH. CO., LTD

  公开号：US11260068B2

  公开（公告）日：2022-03-01

  The present invention relates to a long-circulating liposome modified with c(RGD-ACP-K). The present invention pertains to the field of pharmaceutical preparations, in particular to the field of targeted pharmaceutical preparations. More specifically, the present invention relates to a long-circulating liposome, the surface of the liposome being modified with c(RGD-ACP-K), and the liposome comprising doxorubicin or a pharmaceutically acceptable salt thereof such as doxorubicin hydrochloride as an anti-cancer active agent. The long-circulating liposome can targetedly deliver the anti-cancer active agent into tumor neovascular endothelial cells and tumor cells and can prolong the circulation time of the liposome in vivo, thereby enhancing the therapeutic effect of anti-tumor medicaments.

  本发明涉及一种用 c(RGD-ACP-K)修饰的长循环脂质体。本发明涉及药物制剂领域，特别是靶向药物制剂领域。更具体地说，本发明涉及一种长循环脂质体，脂质体的表面用c(RGD-ACP-K)修饰，脂质体包含作为抗癌活性剂的多柔比星或其药学上可接受的盐，如盐酸多柔比星。长循环脂质体可将抗癌活性剂靶向递送到肿瘤新生血管内皮细胞和肿瘤细胞中，延长脂质体在体内的循环时间，从而提高抗肿瘤药物的治疗效果。
• LIPIDS, LIPID COMPOSITIONS, AND METHODS OF USING THEM
  申请人：Novartis AG

  公开号：EP2516010A2

  公开（公告）日：2012-10-31
• METHODS AND COMPOSITIONS FOR INTERFERENCE WITH DNA POLYMERASE AND DNA SYNTHESIS
  申请人：SeNa Research, Inc.

  公开号：EP3044314B1

  公开（公告）日：2019-04-10
• POLYNUCLEOTIDES, COMPOSITIONS, AND METHODS FOR GENOME EDITING
  申请人：Intellia Therapeutics, Inc.

  公开号：EP3687581A1

  公开（公告）日：2020-08-05