lycoricidine | 19622-83-4

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 石蒜科生物碱
• 英文名称: lycoricidine
• 英文别名: Lycoricidin B；2,3,4-trihydroxy-3,4,4a,5-tetrahydro-2H-[1,3]dioxolo[4,5-j]phenanthridin-6-one
• CAS: 19622-83-4；58207-40-2；149880-98-8
• 化学式: C₁₄H₁₃NO₆
• 分子量: 291.26
• InChiKey: YYDLFVZOIDOGSO-UHFFFAOYSA-N

物化性质

• 熔点：
  214.5-215.5 °C (decomp)
• 沸点：
  677.6±55.0 °C(Predicted)
• 密度：
  1.72±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  21
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  108
• 氢给体数：
  4
• 氢受体数：
  6

制备方法与用途

7-去氧 Narciclasine可以从海慈百合中分离获得，具有抑制癌细胞生长的作用。

文献信息

• Use of an extract of Lycoris chejuenis and/or a compound isolated therefrom for preventing and/or treating a neurodegenerative disease
  申请人：Korea Institute of Science and Technology

  公开号：EP2226077A1

  公开（公告）日：2010-09-08

  Provided are novel use of an extract of Lycoris chejuensis or a compound isolated therefrom for inhibition of β-amyloid production and/or prevention, improvement and/or treatment of a neurodegenerative disease, more specifically a β-amyloid production inhibitor, and/or a composition for prevention or treatment of a neurodegenerative disease containing one or more kinds selected from the group consisting of an extract of Lycoris chejuensis, and/or dihydrolycoricidinc, 2-methoxypancracinc, lycoricidine, and/or lycoricidinol, as an active ingredient; a method for inhibiting β-amyloid production, and/or preventing and/or treating a neurodegenerative disease using the same; and, a method for preparing the same.

  提供了一种新的用途，即利用枸杞提取物或从中分离出的化合物来抑制β-淀粉样蛋白的产生和/或预防、改善和/或治疗神经退行性疾病，更具体地说是一种β-淀粉样蛋白产生抑制剂、和/或一种用于预防或治疗神经退行性疾病的组合物，该组合物含有一种或多种选自由枸杞提取物、和/或二氢枸杞醇、2-甲氧基潘枸杞醇、枸杞苷和/或枸杞醇组成的组的活性成分；一种抑制β-淀粉样蛋白生成的方法，和/或使用该方法预防和/或治疗神经退行性疾病；以及一种制备该方法的方法。
• Compositions, methods, and plant genes for the improved production of fermentable sugars for biofuel production
  申请人：The Governing Council of the University of Toronto

  公开号：US10760087B2

  公开（公告）日：2020-09-01

  Described herein are compositions comprising at least one auxin transport inhibitor for pre-treating a plant or seed to increase saccharification, or saccharide release by hydrolysis, the at least one auxin transport inhibitor being in an amount effective to increase sugar release from a plant tissue by hydrolysis. Also described are plant mutations, and methods to screen for such plant mutations, having an improved sugar release phenotype. The described compositions, methods and plant mutations are particularly useful for producing biofuel crops, such as maize, to improve sugar extractability from lignocellulosic biomass and hence, the efficiency of bioethanol production overall.

  本文描述了包含至少一种辅助素转运抑制剂的组合物，用于预处理植物或种子以增加糖化或通过水解释放糖，至少一种辅助素转运抑制剂的有效量可增加通过水解从植物组织中释放糖。还描述了具有改进的糖释放表型的植物突变和筛选这种植物突变的方法。所述组合物、方法和植物突变特别适用于生物燃料作物（如玉米）的生产，以提高从木质纤维素生物质中提取糖的能力，从而提高生物乙醇的总体生产效率。
• Extract of Lycoris chejuenis and/or a compound isolated therefrom for preventing and/or treating a neurodegenerative disease
  申请人：Korea Institute of Science and Technology

  公开号：EP2226077B1

  公开（公告）日：2017-05-03
• Method of preventing and/or treating a neurodegenerative disease by administering an extract of Lycoris chejuensis and/or a compound isolated therefrom
  申请人：Yang Hyun-Ok

  公开号：US20100227851A1

  公开（公告）日：2010-09-09

  Provided are novel use of an extract of Lycoris chejuensis or a compound isolated therefrom for inhibition of β-amyloid production and/or prevention, improvement and/or treatment of a neurodegenerative disease, more specifically a β-amyloid production inhibitor, and/or a composition for prevention or treatment of a neurodegenerative disease containing one or more kinds selected from the group consisting of an extract of Lycoris chejuensis , and/or dihydrolycoricidine, 2 -methoxypancracine, lycoricidine, and/or lycoricidinol, as an active ingredient; a method for inhibiting β-amyloid production, and/or preventing and/or treating a neurodegenerative disease using the same; and, a method for preparing the same.
• COMPOSITION FOR PREVENTING OR TREATING DEMENTIA
  申请人：Yang Hyun Ok

  公开号：US20130261147A1

  公开（公告）日：2013-10-03

  There is provided use of Lycoris aurea extracts, and/or fractions thereof, and/or lycoricidine and lycoricidinol separated from the extracts or fractions for prevention and/or treatment of dementia.