5-Oxo-5-p-tolyl-valeriansaeure-amid | 91640-59-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-Oxo-5-p-tolyl-valeriansaeure-amid
• 英文别名: 5-(4-Methylphenyl)-5-oxopentanamide
• CAS: 91640-59-4
• 化学式: C₁₂H₁₅NO₂
• 分子量: 205.257
• InChiKey: ZAHYNXJIDCFSAJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  60.2
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• 2-ACYLAMINOPROPANOL-TYPE GLUCOSYLCERAMIDE SYNTHASE INHIBITOR
  申请人：Genzyme Corporation

  公开号：EP3078373A1

  公开（公告）日：2016-10-12

  A compound for use in treating polycystic kidney disease is represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. A pharmaceutical composition comprises a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof. A method of treating polycystic kidney disease in a subject in need thereof comprises administering to the subject a therapeutically effective amount of a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof. Methods of treating in polycystic kidney disease in a subject in need thereof respectively comprise administering to the subject a therapeutically effective amount of a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof.

  一种用于治疗多囊肾病的化合物由结构式（I）代表：或其药学上可接受的盐。一种药物组合物包含由结构式（I）代表的化合物或其药学上可接受的盐。一种治疗有需要的受试者的多囊肾病的方法，包括向受试者施用治疗有效量的结构式(I)所代表的化合物或其药学上可接受的盐。分别治疗有需要的受试者的多囊肾病的方法包括向受试者施用治疗有效量的结构式(I)所代表的化合物或其药学上可接受的盐。
• Carbacyclin analogues
  申请人：THE UPJOHN COMPANY

  公开号：EP0087237B1

  公开（公告）日：1986-05-14
• 9-Substituted carbacyclin analogues
  申请人：THE UPJOHN COMPANY

  公开号：EP0086611B1

  公开（公告）日：1986-05-21
• 9-Substituted carbacyclins
  申请人：THE UPJOHN COMPANY

  公开号：EP0092352B1

  公开（公告）日：1986-07-02
• SUBSTITUTED (SULFINIC ACID, SULFONIC ACID, SULFONYLAMINO OR SULFINYLAMINO) N- (AMINOIMINOMETHYL)PHENYLALKYL -AZAHETEROCYCLYLAMIDE COMPOUNDS
  申请人：Aventis Pharmaceuticals Inc.

  公开号：EP0853618B1

  公开（公告）日：2011-08-17