4-Aminophenyl-beta-D-glucuronide

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-Aminophenyl-beta-D-glucuronide
• 英文别名: 6-(4-aminophenoxy)-3,4,5-trihydroxyoxane-2-carboxylic acid
• 化学式: C₁₂H₁₅NO₇
• 分子量: 285.25
• InChiKey: ZARKEMJKQOXOSQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  143
• 氢给体数：
  5
• 氢受体数：
  8

文献信息

• HUMAN BETA-GLUCURONIDASE MUTANTS WITH ELEVATED ENZYMATIC ACTIVITY UNDER PHYSIOLOGICAL CONDITIONS AND METHOD FOR IDENTIFYING SUCH
  申请人：Roffler Steve

  公开号：US20100129367A1

  公开（公告）日：2010-05-27

  A number of human beta-glucuronidase variants having higher enzymatic activity at physiological pH as compared with wild-type beta-glucuronidase and uses thereof in prodrug therapy. Also disclosed herein is a method for identifying enzyme variants having elevated enzymatic activity using a mammalian surface display system.