4'-propoxy-4-methylbiphenyl | 245056-75-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4'-propoxy-4-methylbiphenyl
• 英文别名: 1-Methyl-4-(4-propoxyphenyl)benzene
• CAS: 245056-75-1
• 化学式: C₁₆H₁₈O
• 分子量: 226.318
• InChiKey: CZUWTAGQSBUAAJ-UHFFFAOYSA-N

物化性质

• 沸点：
  344.2±21.0 °C(Predicted)
• 密度：
  0.992±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4'-propoxy-4-methylbiphenyl 在 zirconium oxide 、 锰 、 钴 sodium bromide 作用下， 以 乙酸酐 、 溶剂黄146 为溶剂， 以77%的产率得到4-丙氧基-4’-二苯甲酸
  参考文献：
  名称：

  Brilev, V. V.; Vasilevskii, D. A.; Tarasevich, V. A., Russian Journal of General Chemistry, 1999, vol. 69, # 1, p. 122 - 125

  摘要：

  DOI：
• 作为产物：
  描述：

  4-methyl-1,1-bis(4'-hydroxyphenyl)cyclohexane 在 palladium on activated charcoal 作用下， 生成 4'-propoxy-4-methylbiphenyl
  参考文献：
  名称：

  Brilev, V. V.; Vasilevskii, D. A.; Tarasevich, V. A., Russian Journal of General Chemistry, 1999, vol. 69, # 1, p. 122 - 125

  摘要：

  DOI：

文献信息

• MELANIN PRODUCTION INHIBITOR
  申请人：Yokoyama Kouji

  公开号：US20110243865A1

  公开（公告）日：2011-10-06

  Disclosed is a melanin production inhibitor which has an excellent inhibitory activity on the production of melanin and is highly safe. The melanin production inhibitor comprises a compound represented by general formula (1) (excluding clotrimazole), and/or a pharmacologically acceptable salt thereof. In the formula, A1, A2 and A3 are independently selected from a hydrogen atom, an aryl group which may have a substituent, and an aromatic heterocyclic group which may have a substituent, wherein at least one of A1, A2 and A3 is selected from the aryl group and the aromatic heterocyclic group, the total number of carbon atoms contained in A1, A2 and A3 is 6 to 50 and, when at least two of A1, A2 and A3 represent the aryl groups or the aromatic heterocyclic groups, the adjacent two aryl or aromatic heterocyclic groups may be bound to each other via an alkyl chain or an alkenyl chain to form a ring; m represents an integer of 0 to 2; X represents a hetero atom, a hydrogen atom, or a carbon atom; R1 and R2 are independently selected from a hydrogen atom and an oxo group, wherein when one of R1 and R2 is an oxo group, the other is not present; and R3 is selected from a hydrogen atom, and a C 1-8 hydrocarbon group in which one or some of hydrogen atoms or carbon atoms may be substituted by a hetero atom or hetero atoms, wherein the number of R3's present in the compound corresponds to the number of X's and, when two or more R3's are present, the R3's are independently present and the adjacent two R3's may be bound to each other to form, together with X, a ring, and the terminal of R3 may be bound to a carbon atom to which A1, A2 and A3 are bound, thereby forming a ring.

  披露了一种黑色素生产抑制剂，它对黑色素的生产具有出色的抑制活性且高度安全。该黑色素生产抑制剂包括由通用公式（1）表示的化合物（不包括克霉唑）和/或其药理上可接受的盐。在公式中，A1、A2和A3独立地选自氢原子、可能带有取代基的芳基团和可能带有取代基的芳香杂环团，其中至少A1、A2和A3之一选自芳基团和芳香杂环团，A1、A2和A3中包含的碳原子总数为6至50，并且当至少两个A1、A2和A3表示芳基团或芳香杂环团时，相邻的两个芳基或芳香杂环团可以通过烷基链或烯基链相互连接形成环；m代表0至2的整数；X代表异原子、氢原子或碳原子；R1和R2独立地选自氢原子和氧代基，其中当R1和R2之一是氧代基时，另一个不出现；R3选自氢原子和C 1-8 碳氢化合物组，其中一些或所有的氢原子或碳原子可能被异原子或异原子取代，其中化合物中存在的R3的数量对应于X的数量，并且当存在两个或更多R3时，R3独立地存在，并且相邻的两个R3可以相互连接以与X一起形成环，并且R3的末端可以与A1、A2和A3连接的碳原子结合，从而形成环。
• Oxadiazole derivative, and light emitting element, light emitting device, and electronic device using the oxadiazole derivative
  申请人：Murata Hiroko

  公开号：US20070149784A1

  公开（公告）日：2007-06-28

  An oxadiazole derivative represented by the following general formula (G1) is synthesized and applied to the light emitting element, wherein A m is a substituent represented by a general formula (Am1), (Am2), or (Am3); each of α, β 1 , and β 2 represents an arylene group having 6 to 25 carbon atoms; each of A r 1 to A r 6 represents an aryl group having 6 to 25 carbon atoms; each of R 1 to R 3 represents hydrogen, an alkyl group having 1 to 4 carbon atoms, or an aryl group having 6 to 25 carbon atoms; and R 4 represents an alkyl group having 1 to 4 carbon atoms or an aryl group having 6 to 25 carbon atoms.

  由以下一般式（G1）表示的一种噁二唑衍生物被合成并应用于发光元件，其中Am是由一般式（Am1）、（Am2）或（Am3）表示的取代基；α、β1和β2分别表示具有6至25个碳原子的芳基基团；Ar1至Ar6分别表示具有6至25个碳原子的芳基基团；R1至R3分别表示氢、具有1至4个碳原子的烷基基团或具有6至25个碳原子的芳基基团；R4表示具有1至4个碳原子的烷基基团或具有6至25个碳原子的芳基基团。
• Oxadiazole Derivative, and Light Emitting Element, Light Emitting Device, and Electronic Device Using the Oxadiazole Derivative
  申请人：Semiconductor Energy Laboratory Co., Ltd.

  公开号：US20140299822A1

  公开（公告）日：2014-10-09

  An oxadiazole derivative represented by the following general formula (G1) is synthesized and applied to the light emitting element, A m ; wherein A m is a substituent represented by a general formula (Am1), (Am2), or (Am3); each of α, β 1 , and β 2 represents an arylene group having 6 to 25 carbon atoms; each of A r 1 to A r 6 represents an aryl group having 6 to 25 carbon atoms; each of R 1 to R 3 represents hydrogen, an alkyl group having 1 to 4 carbon atoms, or an aryl group having 6 to 25 carbon atoms; and R 4 represents an alkyl group having 1 to 4 carbon atoms or an aryl group having 6 to 25 carbon atoms.

  以下为一氧二唑衍生物的通式（G1），并应用于发光元件Am，其中Am是由通式（Am1）、（Am2）或（Am3）表示的取代基；α、β1和β2分别表示具有6至25个碳原子的芳基基团；Ar1至Ar6分别表示具有6至25个碳原子的芳基基团；R1至R3分别表示氢、具有1至4个碳原子的烷基基团或具有6至25个碳原子的芳基基团；R4表示具有1至4个碳原子的烷基基团或具有6至25个碳原子的芳基基团。
• SPIROCYCLIC COMPOUNDS AS TRYPTOPHAN HYDROXYLASE INHIBITORS
  申请人：Karos Pharmaceuticals, Inc.

  公开号：US20150080393A1

  公开（公告）日：2015-03-19

  The present invention is directed to spirocyclic compounds which are inhibitors of tryptophan hydroxylase (TPH), particularly isoform 1 (TPH1), that are useful in the treatment of diseases or disorders associated with peripheral serotonin including, for example, gastrointestinal, cardiovascular, pulmonary, inflammatory, metabolic, and low bone mass diseases, as well as serotonin syndrome, and cancer.

  本发明涉及螺环化合物，它们是色氨酸羟化酶（TPH）的抑制剂，特别是isoform 1（TPH1），可用于治疗与外周血清素相关的疾病或疾病，例如胃肠道、心血管、肺部、炎症、代谢和低骨量疾病，以及血清素综合症和癌症。
• POLYMERIZABLE LIQUID CRYSTAL COMPOSITION AND OPTICALLY ANISOTROPIC BODY
  申请人：Dainippon Ink and Chemicals, Incorporated

  公开号：EP1754768A1

  公开（公告）日：2007-02-21

  A polymerizable liquid crystal composition includes a liquid crystal compound having a polymerizable group, wherein the composition includes from 0.1 to 6.0% by weight of a (meth)acrylic copolymer (H), which 1) has a side chain containing a fluorine group, and a side chain containing a group represented by a general formula (h): 2) has a fluorine group content of 3 to 30% by weight, 3) has a ratio of side chains containing the group represented by the general formula (h) relative to the combined total of all side chains that falls within a range from 9 to 95 mol%, and 4) has a weight average molecular weight within a range from 10,000 to 300,000.

  一种可聚合液晶组合物包括具有可聚合基团的液晶化合物，其中该组合物包括 0.1 至 6.0%（重量）的(甲基)丙烯酸共聚物(H)，该共聚物(H) 1) 具有含氟基团的侧链和含通式 (h) 所代表基团的侧链： 2）氟基含量为 3%至 30%（按重量计）、 3）含有通式（h）所代表基团的侧链相对于所有侧链总和的比例在 9 至 95 摩尔%的范围内，且 4) 平均分子量在 10,000 至 300,000 之间。