nonanal (2,4-dinitrophenyl)hydrazone | 2348-19-8

• 物质功能分类: 分析化学 - 标准品 - 有机污染物标样
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: nonanal (2,4-dinitrophenyl)hydrazone
• 英文别名: 2,4-dinitrononanal phenylhydrazine；nonanal-(2,4-dinitro-phenylhydrazone)；Nonanal-(2,4-dinitro-phenylhydrazon)；Pelargonaldehyd-(2.4-dinitro-phenylhydrazon)；Nonanaldehyd-<2.4-dinitro-phenylhydrazon>；Nonanal-<2.4-dinitro-phenylhydrazon>；Pelargonaldehyde,dnph deriv；2,4-dinitro-N-(nonylideneamino)aniline
• CAS: 2348-19-8；74335-75-4；74335-76-5
• 化学式: C₁₅H₂₂N₄O₄
• 分子量: 322.364
• InChiKey: STBNOHBRCCXRIK-UHFFFAOYSA-N

物化性质

• 熔点：
  99-103 °C
• 沸点：
  458.3±45.0 °C(Predicted)
• 密度：
  1.21±0.1 g/cm3(Predicted)
• 保留指数：
  2857

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  23
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  116
• 氢给体数：
  1
• 氢受体数：
  6

安全信息

• 危险品标志：
  Xi
• 安全说明：
  S26
• 危险类别码：
  R36/37/38
• WGK Germany：
  3

反应信息

• 作为反应物：
  描述：

  nonanal (2,4-dinitrophenyl)hydrazone 在 溴 、 乙酸酐 作用下， 以 溶剂黄146 为溶剂， 以70%的产率得到
  参考文献：
  名称：

  取代的的卤化。合成一些新的酰肼基卤化物的简便方法

  摘要：

  DOI：

  10.1021/je00026a022
• 作为产物：
  描述：

  5-丁基噻吩-2-甲醛 在 盐酸 、 乙醚 、 乙醇 、 镍 作用下， 生成 nonanal (2,4-dinitrophenyl)hydrazone
  参考文献：
  名称：

  Gol'dfarb; Konstantinow, Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1957, p. 217,219; engl. Ausg. S. 229, 231

  摘要：

  DOI：

文献信息

• Formation of potentially toxic carbonyls during oxidation of triolein in the presence of alimentary antioxidants
  作者：Marini Damanik、Michael Murkovic

  DOI：10.1007/s00706-017-2036-3

  日期：2017.12

  inflammation was shown earlier. It is discussed that the main oil oxidation products—hydroperoxides and carbonyls—might be the reason for the mentioned diseases. In this manuscript quantitative determination of aldehydes which are formed during oxidation of triolein—as a model substance—using the Rancimat 679 is described. The oxidation of 11 g of triolein is carried out at 120 °C sparging air with a

  摘要较早的研究表明，油的摄入与癌症以及肝脏炎症的诱导之间存在关系。据讨论，主要的石油氧化产物——氢过氧化物和羰基化合物——可能是上述疾病的原因。在本手稿中，描述了使用 Rancimat 679 对三油酸甘油酯（作为模型物质）氧化过程中形成的醛进行定量测定。11 g 三油酸甘油酯的氧化在 120 °C 下以 20 dm 3 /h的流量喷射空气进行10 h。通过 LC-MS/MS 鉴定了从己醛到癸醛以及癸醛的一系列脂肪醛，并定量为 DNPH 衍生物。另外，测定了羰基的总量。基于己醛校准，所有其他主要物质都在相似的浓度范围内，最大浓度为己醛1.6 µmol/cm 3、庚醛2.3 µmol/cm 3、辛醛2.5 µmol/cm 3、3.2 µmol/cm 3 。壬醛，6 小时后 4.0 µmol/cm 3癸醛。对于不含抗氧化剂的三油酸酯，6小时后羰基总量达到最大值，为27 µmol/cm 3。这项
• Lower Extremity Blood Flow in Healthy Men: Effect of Smoking, Cholesterol, and Physical Activity — A Doppler Study
  作者：Lilja Petra Ásgeirsdóttir、Uggi Agnarsson、Guomundur S. Jónsson

  DOI：10.1177/000331970105200701

  日期：2001.7

  Tobacco smoking is one of the principal risk factors of peripheral arterial disease (PAD); choles terol level has a lesser impact. The effect of leisure-time physical activity (LTPA) has not been studied in depth. The aim of this study was to determine the relative effects of smoking, total cholesterol, and leisure-time physical activity on blood flow parameters in the lower extremi ties of healthy middle-aged men with no prior symptoms or diagnosis of PAD.

  The authors examined 130 men, aged 40-65 years, free of known arterial disease and hypertension. The men had either a total cholesterol concentration of <5.7 or > 7.0 mmol/L, and were either smokers or nonsmokers. LTPA was addressed by a questionnaire. Ankle-brachial index (ABI) was calculated and Doppler examination of the femoral artery was performed before and after an exercise test.

  Tobacco smoking related significantly to abnormal ABI and Doppler results (odds ratio [OR] 2.42) while the total cholesterol level did not. LTPA had a favorable effect (OR 0.51). Abnormal ABI response was greatest in smokers with high total cholesterol (p < 0.01).

  Tobacco smoking is a significant risk factor for abnormal ABI response and blood flow abnormalities in healthy men. Regular physical activity has a measurable protective effect. An abnormal ABI suggests early atherosclerosis and indicates risk factor assessment and physician intervention.

  吸烟是外周动脉疾病（PAD）的主要危险因素之一；胆固醇水平的影响较小。休闲时间的体育活动（LTPA）的影响尚未深入研究。本研究旨在确定吸烟、总胆固醇和休闲时间体育活动对未出现PAD症状或诊断的健康中年男性下肢血流参数的相对影响。 作者研究了130名40-65岁的男性，他们没有已知的动脉疾病和高血压。这些男性的总胆固醇浓度要么小于5.7毫摩尔/升，要么大于7.0毫摩尔/升，他们要么吸烟要么不吸烟。通过问卷调查了休闲时间体育活动。计算了踝臂指数（ABI），并在运动测试前后对股动脉进行多普勒检查。 吸烟与ABI和多普勒结果异常显著相关（比值比[OR] 2.42），而总胆固醇水平则没有。LTPA具有有利影响（OR 0.51）。吸烟者中总胆固醇高的人ABI反应异常最严重（p <0.01）。 吸烟对健康男性的ABI反应异常和血流异常是一个重要的危险因素。定期的体育活动具有可测量的保护作用。异常的ABI表明早期动脉粥样硬化，并提示风险因素评估和医师干预。
• Acetylenic Strongylodiols from a <i>Petrosia</i> (<i>Strongylophora</i>) Okinawan Marine Sponge
  作者：Kinzo Watanabe、Yuichiro Tsuda、Maki Hamada、Miki Omori、Go Mori、Kazuo Iguchi、Hideo Naoki、Tsuyoshi Fujita、Rob W. M. Van Soest

  DOI：10.1021/np040233u

  日期：2005.7.1

  Seven new long-chain acetylenic alcohols, strongylodiols D-J, were isolated from an Okinawan marine sponge of the genus Petrosia (Strongylophora). The structures of these compounds were elucidated on the basis of the results of spectroscopic analysis and chemical reaction. Analysis of the MNA esters of the acetylenic alcohols disclosed that these compounds were each an enantiomeric mixture in a different

  从Petrosia（Strongylophora）属的冲绳海洋海绵中分离出七种新的长链炔属醇，即强稠二醇DJ。根据光谱分析和化学反应的结果阐明了这些化合物的结构。对炔属醇的MNA酯的分析表明，这些化合物各自是以不同比例的对映体混合物。
• Photoalkylation of cyclic acetals
  作者：I. Rosenthal、Dov Elad

  DOI：10.1021/jo01266a067

  日期：1968.2
• 1-(Carbazol-9-ylmethyl)benzotriazole anion: a formyl anion equivalent
  作者：Alan R. Katritzky、Zhijun Yang、Jamshed N. Lam

  DOI：10.1021/jo00006a034

  日期：1991.3

  The title anion, readily available as its lithium derivative, smoothly reacts with a wide range of electrophiles to give well-characterized products which are easily hydrolyzed to the corresponding aldehydes in high overall yields. The method is compared with currently available routes.