(S)-2-((2S,3R,4R)-3,4-Dihydroxy-5-oxotetrahydrofuran-2-yl)-2-hydroxyacetic acid hydrate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: (S)-2-((2S,3R,4R)-3,4-Dihydroxy-5-oxotetrahydrofuran-2-yl)-2-hydroxyacetic acid hydrate
• 英文别名: (2S)-2-[(2S,3R,4R)-3,4-dihydroxy-5-oxooxolan-2-yl]-2-hydroxyacetic acid;hydrate
• 化学式: C6H10O8
• 分子量: 210.14
• InChiKey: NPFKVZHSFSFLPU-QGBSHYGGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.75
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  125
• 氢给体数：
  5
• 氢受体数：
  8

文献信息

• THERAPEUTIC AGENTS
  申请人：Takara Shuzo Co, Ltd.

  公开号：EP1099440A1

  公开（公告）日：2001-05-16

  Therapeutic or preventive agents for diseases due to the action of aldose reductase; and aldose reductase inhibitors, characterized by containing at least one compound having an aldose reductase inhibiting activity which is selected from among 2,5-dihydroxytetra-hydro-2-furancarboxylic acid, derivatives of the same, optical isomers of both and pharmacologically acceptable salts of them.

  醛糖还原酶抑制剂，其特征是含有至少一种具有醛糖还原酶抑制活性的化合物，该化合物选自2,5-二羟基四氢-2-呋喃甲酸、其衍生物、二者的光学异构体及其药理学上可接受的盐类。
• ENZYME ASSAYS ON A DROPLET ACTUATOR
  申请人：Advanced Liquid Logic, Inc.

  公开号：EP2516669A2

  公开（公告）日：2012-10-31
• US6492338B1
  申请人：——

  公开号：US6492338B1

  公开（公告）日：2002-12-10
• [EN] ENZYME ASSAYS ON A DROPLET ACTUATOR<br/>[FR] ANALYSES D'ENZYMES SUR UN DIFFUSEUR À GOUTTELETTES
  申请人：ADVANCED LIQUID LOGIC INC

  公开号：WO2011084703A2

  公开（公告）日：2011-07-14

  The invention is directed to droplet actuator devices and assay methods for multiplexed newborn testing for metabolic disorders. The methods include, among other things, droplet-based enzymatic assays and immunoassays for testing for metabolic disorders. The invention includes methods and devices for conducting multiple assays for different metabolic disorders on a single droplet actuator, as well as multiple assays for the same metabolic disorder using samples from different subjects and/or multiple samples from the same subject on a single droplet actuator. In various embodiments, the invention includes methods for conducting enzymatic activity assays and/or immunoassays in a single fresh blood and/or plasma samples and dried blood and/or plasma samples.