α-phenyl-β-bromopropionic acid | 5441-68-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: α-phenyl-β-bromopropionic acid
• 英文别名: 2-phenyl-3-bromopropanoic acid；3-bromo-2-phenyl-propionic acid；3-Brom-2-phenyl-propionsaeure；β-Brom-α-phenyl-propionsaeure；β-Brom-hydratropasaeure；3-bromo-2-phenylpropionic acid；3-Bromo-2-phenylpropanoic acid
• CAS: 5441-68-9；62328-52-3；62328-53-4
• 化学式: C₉H₉BrO₂
• 分子量: 229.073
• InChiKey: REKPUONWQOZKPH-UHFFFAOYSA-N

物化性质

• 沸点：
  295.4±28.0 °C(Predicted)
• 密度：
  1.554±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  α-phenyl-β-bromopropionic acid 在 氯化亚砜 作用下， 生成 3-bromo-2-phenyl-propionyl chloride
  参考文献：
  名称：

  PIFFERI; CIGNARELLA; CRISTIANI, Farmaco, Edizione Scientifica, 1963, vol. 18, p. 658 - 667

  摘要：

  DOI：
• 作为产物：
  描述：

  atropine 在 barium dihydroxide 、 氢溴酸 作用下， 生成 α-phenyl-β-bromopropionic acid
  参考文献：
  名称：

  Fittig; Wurster, Justus Liebigs Annalen der Chemie, 1879, vol. 195, p. 147

  摘要：

  DOI：

文献信息

• [EN] ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITION THEREOF<br/>[FR] DÉRIVÉS AMINOESTER D'ALKALOÏDES ET COMPOSITION MÉDICINALE LES COMPRENANT
  申请人：CHIESI FARMA SPA

  公开号：WO2011160919A1

  公开（公告）日：2011-12-29

  The present invention relates to alkaloid aminoester derivatives acting as muscarinic receptor antagonists, processes for their preparation, compositions comprising them and therapeutic uses thereof.

  本发明涉及作为毒蕈碱受体拮抗剂的生物碱氨基酸酯衍生物，它们的制备方法，包含它们的组合物及其治疗用途。
• DYE CONJUGATES AND METHODS OF USE
  申请人：Dehghani Ali

  公开号：US20100291706A1

  公开（公告）日：2010-11-18

  The present invention relates to cyanine compounds, compositions comprising them, articles of manufacture, and methods of making and using them. The cyanines usefully comprise one or more carboxyl groups or derivatives thereof that are indirectly attached to an aryl ring on an alkylaryl cyanine substituent. Also provided are conjugates of the disclosed cyanines and one or more other substances. Solvates, solutions, and derivatized forms of the cyanines are also provided. The cyanines find use in a variety of bioassays, both in direct single-label applications and in energy transfer formats. Methods utilizing the disclosed cyanines for analyzing a sample for a target are provided. Also disclosed are detection complexes comprising the disclosed cyanines, as well as compositions and articles comprising the cyanines in an excited state, for example formed by direct excitation or by energy transfer. The cyanines may be used as alternatives to other known optically active species in a variety of settings. Other embodiments are described further herein.

  本发明涉及青色素化合物、包含它们的组合物、制造品以及它们的制造和使用方法。有用的青色素包含一个或多个羧基或其衍生物，这些羧基或其衍生物间接连接到烷基芳基青色素取代基上的芳环上。还提供了所披露的青色素与一个或多个其他物质的结合物。还提供了青色素的溶剂化物、溶液和衍生化形式。青色素在多种生物检测中找到了用途，既适用于直接单标记应用，也适用于能量转移格式。提供了利用所披露的青色素分析样品中目标物的方法。还披露了包含所披露青色素的检测复合物，以及包含处于激发态的青色素的组成和物品，例如通过直接激发或能量转移形成的。青色素可以用作各种场合中其他已知光活性物种的替代品。其他实施方式在本发明中进一步描述。
• [EN] KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME<br/>[FR] INHIBITEURS DE KINASES ET PROCÉDÉ DE TRAITEMENT DU CANCER UTILISANT CEUX-CI
  申请人：UNIV HEALTH NETWORK

  公开号：WO2011123937A1

  公开（公告）日：2011-10-13

  The present teachings provide a compound represented by Strutural Formula (I): or a pharmaceutically acceptable salt thereof. Also described are a pharmaceutical composition and method of use thereof.

  本教学提供了一种由结构式(I)表示的化合物，或其药用可接受的盐。还描述了一种药物组合物及其使用方法。
• [EN] HYDROXAMATE SULFONAMIDES AS CD23 SHEDDING INHIBITORS<br/>[FR] SULFONAMIDES D'HYDROXAMATE SERVANT D'INHIBITEURS D'ELIMINATION DU VIRUS CD23
  申请人：CELLTECH R&D LTD

  公开号：WO2004113312A1

  公开（公告）日：2004-12-29

  A class of piperazine and related heterocyclic derivatives, substituted at the 4-position by a substituted aryl or heteroaryl moiety, and at the 1-position by an ethylsulfonyl group which in turn is substituted at the 2-position by a hydroxamic acid moiety and also by a range of alternative substituents, being potent inhibitors of CD23 shedding, are useful in the treatment and/or prevention of allergic, inflammatory and neoplastic diseases.

  一类哌嗪和相关杂环衍生物，其在4位被取代芳基或杂环基取代，并在1位被乙磺酰基取代，乙磺酰基在2位被羟肟酸基取代，同时还被一系列替代基取代，这些化合物是CD23脱落的有效抑制剂，可用于治疗和/或预防过敏、炎症和肿瘤性疾病。
• [EN] AZO COMPOUND, PIGMENT DISPERSANT CONTAINING THE AZO COMPOUND, PIGMENT COMPOSITION, PIGMENT DISPERSION AND TONER<br/>[FR] COMPOSÉ AZOÏQUE, DISPERSANT DE PIGMENT CONTENANT LE COMPOSÉ AZOÏQUE, COMPOSITION DE PIGMENT, DISPERSION DE PIGMENT ET TONER
  申请人：CANON KK

  公开号：WO2013129696A1

  公开（公告）日：2013-09-06

  An object of the present invention is to provide an azo compound capable of improving the dispersibility of an azo pigment in a non-water-soluble solvent. The object of the present invention is achieved with an azo compound wherein a coloring matter moiety having a diketone azo structure and a polymer are bonded to each other.

  本发明的目的是提供一种偶氮化合物，能够改善偶氮颜料在非水溶性溶剂中的分散性。本发明的目的通过一种偶氮化合物实现，其中具有二酮偶氮结构的着色物基团和聚合物彼此结合。