10,10-dimethyl-7-(4-hydroxy-3-methoxyphenyl)-10,11-dihydrochromeno[4,3-b]chromene-6,8(7H,9H)-dione | 1309477-40-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 10,10-dimethyl-7-(4-hydroxy-3-methoxyphenyl)-10,11-dihydrochromeno[4,3-b]chromene-6,8(7H,9H)-dione
• 英文别名: 7-(4-hydroxy-3-methoxyphenyl)-10,10-dimethyl-9,11-dihydro-7H-chromeno[3,2-c]chromene-6,8-dione
• CAS: 1309477-40-4
• 化学式: C₂₅H₂₂O₆
• 分子量: 418.446
• InChiKey: NIXQHBKIJXTRCQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  31
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  82.1
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  4-羟基香豆素 、 5,5-二甲基-1,3-环己二酮 、 香草醛 在 碘 、 溶剂黄146 作用下， 反应 0.12h， 以70%的产率得到10,10-dimethyl-7-(4-hydroxy-3-methoxyphenyl)-10,11-dihydrochromeno[4,3-b]chromene-6,8(7H,9H)-dione
  参考文献：
  名称：

  微波辐射下四氢苯并[c]呫吨-1,11-二酮衍生物的高效一锅法合成

  摘要：

  摘要 以分子碘为催化剂，通过常规加热和微波辐照技术实现了 4-羟基香豆素、芳香醛和 5,5-二甲基环己烷-1,3-二酮的高效一锅缩合反应，从而获得了多种新的以良好的收率制备了四氢苯并[c]呫吨-1,11-二酮衍生物。图形概要

  DOI：

  10.1080/00397911.2010.551285

文献信息

• Patil, Kirti T.; Wakkar; Undare, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2016, vol. 55B, # 9, p. 1151 - 1159
  作者：Patil, Kirti T.、Wakkar、Undare、Kolekar、Deshmukh, Madhukar B.、Choudhari、Anbhule, Prashant V.

  DOI：——

  日期：——
• A novel sulfonic acid functionalized ionic liquid catalyzed multicomponent synthesis of 10,11-dihydrochromeno[4,3-b]chromene-6,8(7H,9H)-dione derivatives in water
  作者：Zhiwei Chen、Qiang Zhu、Weike Su

  DOI：10.1016/j.tetlet.2011.03.059

  日期：2011.5

  Three-component reactions of 4-hydroxycoumarin, aldehydes, and cyclic 1,3-dicarbonyl compounds were prompted by novel sulfonic acid functionalized ionic liquids 1,3-dimethyl-2-oxo-1,3-bis(4-sulfobutyl)imidazolidine-1,3-diium hydrogen sulfate ([DMDBSI]center dot 2HSO(4)) in water at reflux temperature to provide a novel series of 10,11-dihydrochromeno[4,3-b]chromene-6,8(7H,9H)-dione derivatives for the first time in high yields. (C) 2011 Elsevier Ltd. All rights reserved.
• Fe(DS)3, an efficient Lewis acid-surfactant-combined catalyst (LASC) for the one pot synthesis of chromeno[4,3-b]chromene derivatives by assembling the basic building blocks
  作者：Koyel Pradhan、Sanjay Paul、Asish R. Das

  DOI：10.1016/j.tetlet.2013.04.001

  日期：2013.6

  A highly efficient multicomponent heteroannulation protocol for the synthesis of a library of chromeno[4,3-b]chromene derivative has been developed by applying a Lewis acid-surfactant-combined catalyst (LASC) [Fe(DS)(3)]. The LASC converted the initially floating reaction mass into a homogeneous mixture, which on stirring became a turbid emulsion of colloidal aggregates. The shape and size of the colloidal aggregates are confirmed by optical microscopy and DLS. The aqueous reaction medium, dual role of the catalyst in aqueous media, easy recovery of the catalyst, and high yield make the protocol attractive, sustainable, and economical. (C) 2013 Elsevier Ltd. All rights reserved.
• Emtiazi, Hamideh; Amrollahi, Mohammad Ali, South African Journal of Chemistry, 2014, vol. 67, p. 175 - 179
  作者：Emtiazi, Hamideh、Amrollahi, Mohammad Ali

  DOI：——

  日期：——
• Efficient One-Pot Synthesis of Tetrahydrobenzo[<i>c</i>]xanthene-1,11-dione Derivatives Under Microwave Irradiation
  作者：Xiao-Jun Sun、Jian-Feng Zhou、San-Jun Zhi

  DOI：10.1080/00397911.2010.551285

  日期：2012.7.1

  Abstract An efficient one-pot condensation of 4-hydroxylcoumarin, aromatic aldehydes, and 5,5-dimethylcyclohexane-1,3-dione has been achieved with molecular iodine as a catalyst via conventional heating and microwave irradiation techniques, and thus a variety of new tetrahydrobenzo[c]xanthene-1,11-dione derivatives were prepared in good yields. GRAPHICAL ABSTRACT

  摘要 以分子碘为催化剂，通过常规加热和微波辐照技术实现了 4-羟基香豆素、芳香醛和 5,5-二甲基环己烷-1,3-二酮的高效一锅缩合反应，从而获得了多种新的以良好的收率制备了四氢苯并[c]呫吨-1,11-二酮衍生物。图形概要