(Z)-2-bromo-6,6-dimethylhept-2-en-4-yn-1-ol | 1176744-55-0

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 卤代醇
• 英文名称: (Z)-2-bromo-6,6-dimethylhept-2-en-4-yn-1-ol
• CAS: 1176744-55-0
• 化学式: C₉H₁₃BrO
• 分子量: 217.106
• InChiKey: SXZOLSBOADGBJH-YVMONPNESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.31
• 重原子数：
  11.0
• 可旋转键数：
  1.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  20.23
• 氢给体数：
  1.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  (Z)-2-bromo-6,6-dimethylhept-2-en-4-yn-1-ol 、 叔丁基二苯基氯硅烷 在 4-二甲氨基吡啶 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 以57%的产率得到(Z)-(2-bromo-6,6-dimethylhept-2-en-4-ynyloxy)(tertbutyl)diphenylsilane
  参考文献：
  名称：

  Novel stereoselective syntheses of (2E,4E)-4-(4,4-dimethylpent-2-ynylidene)-N1,N5-dimethyl-N1,N5-bis(naphthalen-1-ylmethyl)pent-2-ene-1,5-diamine

  摘要：

  We report two different synthetic approaches for the stereoselective synthesis of (2E,4E)-4-(4,4-dimethylpent-2-ynylidene)-N-1,N-5-dimethyl-N-1,N-5-bis(naphthalen-1-ylmethyl)pent-2-ene-1,5-diamine important impurity-reference standard for the chemical characterization of terbinafine. The diamine 1 was obtained in only six steps with a good overall yield starting from commercially available glutaconic acid. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.04.095
• 作为产物：
  描述：

  (Z)-ethyl 2-bromo-6,6-dimethylhept-2-en-4-ynoate 在 二异丁基氢化铝 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 以64%的产率得到(Z)-2-bromo-6,6-dimethylhept-2-en-4-yn-1-ol
  参考文献：
  名称：

  Novel stereoselective syntheses of (2E,4E)-4-(4,4-dimethylpent-2-ynylidene)-N1,N5-dimethyl-N1,N5-bis(naphthalen-1-ylmethyl)pent-2-ene-1,5-diamine

  摘要：

  We report two different synthetic approaches for the stereoselective synthesis of (2E,4E)-4-(4,4-dimethylpent-2-ynylidene)-N-1,N-5-dimethyl-N-1,N-5-bis(naphthalen-1-ylmethyl)pent-2-ene-1,5-diamine important impurity-reference standard for the chemical characterization of terbinafine. The diamine 1 was obtained in only six steps with a good overall yield starting from commercially available glutaconic acid. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.04.095

文献信息

• Novel stereoselective syntheses of (2E,4E)-4-(4,4-dimethylpent-2-ynylidene)-N1,N5-dimethyl-N1,N5-bis(naphthalen-1-ylmethyl)pent-2-ene-1,5-diamine
  作者：Lino Colombo、Marcello Di Giacomo、Massimo Serra、Simone M. Tambini

  DOI：10.1016/j.tet.2009.04.095

  日期：2009.7

  We report two different synthetic approaches for the stereoselective synthesis of (2E,4E)-4-(4,4-dimethylpent-2-ynylidene)-N-1,N-5-dimethyl-N-1,N-5-bis(naphthalen-1-ylmethyl)pent-2-ene-1,5-diamine important impurity-reference standard for the chemical characterization of terbinafine. The diamine 1 was obtained in only six steps with a good overall yield starting from commercially available glutaconic acid. (C) 2009 Elsevier Ltd. All rights reserved.